Nicotinic acid - instructions for use, dose, side effects, contraindications

Nicotinic acid is a vitamin and hypolipidemic agent. In organism a nicotinic acid turns into nicotinamide, which binds to coenzymes I and II of codegyrogenase I and II (NAD and NADP), which carry hydrogen, participates in the metabolism of fats, proteins, amino acids, purines, tissue respiration, glycogenolysis, synthetic processes. Replenishes the vitamin PP deficiency (vitamin B3), is a specific antipellagic agent (Vitamin PP vitamin avitaminosis).

Normalizes the concentration of blood lipoproteins. Has vasodilating effect at the level of small vessels (including the brain), improves microcirculation, has a weak antiCoagulant action (increases the fibrinolytic activity of the blood).

Pharmacokinetics:

When parenteral administration is rapidly distributed in the tissues of the body. In organism a nicotinic acid turns into nicotinamide. It accumulates mainly in the liver, as well as in adipose tissue and in the kidneys.Metabolised in the liver. The main metabolites are N-methyl-2-pyridone-3-carboxamide and N-methyl-2-pyridone-5-carboxamide which do not possess pharmacological activity.

It is excreted by the kidneys in the form of metabolites, when taking high doses - mostly unchanged.

Indications:

Avitaminosis PP (pellagra). Ischemic disorders of cerebral circulation, obliterating diseases of the vessels of the extremities (obliterating endarteritis, Raynaud's disease), spasms of the vessels of the extremities, biliary and urinary tracts, neuritis of the facial nerve.

Contraindications:Hypersensitivity, severe arterial hypertension, atherosclerosis, gout, hyperuricemia, pregnancy, lactation period, children's age.

Carefully:Hemorrhagia, glaucoma, hepatic insufficiency, arterial hypotension, hyperacid gastritis, peptic ulcer of the stomach and duodenum (in the stage of exacerbation).

Pregnancy and lactation:contraindicated

Dosing and Administration:

With pellagra, subcutaneously, intramuscularly, intravenously (slowly) 10 mg of nicotinic acid (1 ml of a solution of 10 mg / ml) is prescribed 1-2 times a day for 10-15 days.

With ischemic stroke, 10 mg is slowly injected intravenously.

At other indications - on 10 mg 1-2 times a day, within 10-15 days. Higher doses for adults: single dose - 100 mg, daily - 300 mg.

Side effects:

Allergic reactions (skin rash, itchy skin, stridorous breathing). Paresthesia, dizziness, "tides" of blood to the skin of the face, hyperemia of the skin of the face and upper half of the trunk, headache. As a rule, these effects disappear on their own.

After a rapid intravenous injection: orthostatic hypotension, collapse. Local reactions: soreness in places of subcutaneous and intramuscular injection.

Overdose:

High doses of nicotinic acid can cause a temporary rush of blood to the head and upper body, itching, and gastrointestinal upsets.

Treatment: symptomatic.

Interaction:

Care should be taken when combining with hypotensive drugs, anticoagulants and acetylsalicylic acid.

Reduces the toxicity of neomycin and prevents the induced decrease in the concentration of high-density cholesterol and lipoproteins.

Special instructions:

During the treatment it is necessary to monitor the function of the liver.

To prevent complications from the liver it is recommended to include in the diet products rich in methionine (cottage cheese), or use methionine, lipoic acid and other lipotropic drugs.

Effect on the ability to drive transp. cf. and fur:

Form release / dosage:

Solution for injection 10 mg / ml.

1 ml per ampoule. 10 ampoules together with instructions for use and scarifierThe ampoule is placed in a carton of a cartone.

5 ampoules are placed in a contour cellPolyvinylchloride film packagingreadable.

2 contourcell packings together with instructions for use and scarifierRum ampullum is put in a pack of cartone.

When using ampoules with a notch, dot or ring fracture, the ampoule scaper is not inserted.

Packaging:ampoules (10) / complete with scarifier, if necessary for ampoules of this type / - cardboard boxes
ampoules (5) / complete with scarifier, if necessary for ampoules of this type / - packaging, cellular contour-packs, cardboard

Storage conditions:Store in a dark place at a temperature of 0 to 25 "C. Do not freeze. Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002675 / 02

Date of registration:07.08.2008

The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia

Manufacturer: & nbsp

MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia

Information update date: & nbsp13.08.2015

Illustrated instructions

Instructions

A nicotinic acid (Nicotinic acid)