Papaverine - instructions for use, dose, side effects, contraindications

Papaverin lowers the tone of smooth muscles and therefore has a vasodilating and spasmolytic effect. It is an inhibitor of the enzyme phosphodiesterase and causes intracellular accumulation of cyclic 3,5-adenosine monophosphate, which leads to a violation of contractility of smooth muscles and their relaxation during spastic states. The effect of papaverine on the central nervous system is poorly expressed, only in large doses it has some sedative effect.

Indications:

Papaverine is used to treat functional disorders and pain associated with spasms of smooth muscles of vessels, organs of the abdominal cavity and bronchi.

The drug is prescribed for spasms of peripheral vessels (endarteritis, etc.), cerebral vessels, stenocardia (as part of complex therapy), bronchospasm, spasms of smooth muscles of the abdominal cavity organs (pylorirospasm, spastic colitis, cholecystitis, biliary cramps attacks), with urinary tract spasms , renal colic.

Contraindications:Hypersensitivity to the drug, violation of atrioventricular conduction, glaucoma, severe hepatic insufficiency, children under 10 years old, advanced age (risk of hyperthermia).

Carefully:

With caution and in small doses, the drug should be prescribed for elderly and debilitated patients, as well as for patients with craniocerebral trauma, impaired liver and kidney function, hypothyroidism, adrenal insufficiency, prostatic hyperplasia, and patients with supraventricular tachycardia and who are in shock .

Pregnancy and lactation:In pregnancy and lactation, the safety and efficacy of the drug is not established.

Dosing and Administration:

Inside adults take 40-60 mg 3-4 times a day.

Higher doses for adults inside: single dose of 200 mg, daily - 600 mg.

Children aged 10-14 years - 15-20 mg.

Side effects:

There may be allergic reactions, nausea, drowsiness, lower blood pressure, excessive sweating, constipation, arrhythmias (including ventricular extrasystole, partial or complete atrioventricular blockade), increased activity of "liver" transaminases, eosinophilia.

Inform your doctor about any unwanted or unpleasant reactions and sensations.

Overdose:

Symptoms: visual impairment (double vision), weakness, drowsiness, hypotension.

Treatment: gastric lavage (milk, Activated carbon), maintenance of arterial pressure.

Interaction:

Papaverin reduces the antiparkinsonian effect of levodopa. In combination with barbiturates, the spasmolytic effect of papaverine is enhanced. When combined with tricyclic antidepressants, procainamide, reserpine, quinidine, an increase in the hypotensive effect is possible.

Special instructions:

During the treatment period, alcohol intake should be excluded.

In pregnancy and lactation, the safety and efficacy of the drug is not established.

The vasodilating effect is reduced by smoking.

Form release / dosage:

Tablets of 40 mg.

Packaging:

For 10 tablets in a contiguous cell-free or cell pack.

For 100 contour non-jammed packages with an equal number of instructions for use are placed in a cardboard box.

For 10 tablets in cans of orange glass or cans of polymeric.

Each jar or 1, 2 contoured cells with instructions for use in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N001069 / 02

Date of registration:18.11.2008

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp22.08.2015

Illustrated instructions

Instructions

Papaverine (Papaverine)