Papaverine - instructions for use, dose, side effects, contraindications

An inhibitor of phosphodiesterase enzyme and causes intracellular accumulation of cyclic 3 ', 5' and reduced -adenozinmonofosfata the content of calcium, which leads to a violation of contractility of smooth muscles and their relaxation. The effect of papaverine hydrochloride on the central nervous system is poorly expressed, but it has a sedative effect only in large doses.In large doses reduces the excitability of the heart muscle and slows intracardiac conduction.

Indications:

Spasm of peripheral vessels (endarteritis), cerebral vessels, stenocardia (as part of complex therapy), bronchospasm, spasm of smooth muscles of the abdominal cavity organs (pilorospasm, spastic colitis, cholecystitis, bile duct attacks), urinary tract spasm, renal colic.

Contraindications:

Hypersensitivity to the drug, atrioventricular (AV) blockade, glaucoma, severe hepatic insufficiency, old age (risk of hyperthermia), children under 1 year old.

Carefully:

The state after craniocerebral trauma, chronic renal failure, insufficiency of adrenal function, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.

Pregnancy and lactation:The use of the drug during pregnancy and during breastfeeding is justified only if the potential benefit to the mother exceeds the possible risk to the fetus and the baby.

Dosing and Administration:Rectally, adults 0,02-0,04 g (1-2 candles) 2-3 times a day.

Side effects:

Allergic reactions are possible, partial or complete AV blockade, ventricular extrasystole, lowering of arterial pressure (BP), constipation, drowsiness, increased activity of "liver" transaminases, eosinophilia.

Inform the attending physician of the appearance of any undesirable or unpleasant reactions and sensations.

Overdose:

Symptoms: diplopia, weakness, decreased blood pressure, drowsiness.

Treatment: symptomatic (maintenance of blood pressure).

Interaction:

Reduces the antiparkinsonian effect of levodopa and hypotensive effect of methyldopa. In combination with barbiturates, the spasmolytic effect of papaverine hydrochloride is enhanced. When combined with tricyclic antidepressants, procainamide, reserpine, quinidine sulfate, hypotensive effect may increase.

Special instructions:

During the treatment period, alcohol intake should be excluded.

The vasodilating effect is reduced by smoking.

Effect on the ability to drive transp. cf. and fur:Information about the possible effect of the drug on the ability to manage vehicles, mechanisms are absent.

Form release / dosage:Suppositories rectal 0.02 g.

Packaging:5 suppositories in a contiguous cell package. 2 contour packs together with instructions for use are placed in a pack of cardboard.

Storage conditions:

In a dry, protected from light and out of reach of children, at a temperature of 12 to 15 ° C.

Shelf life:

2 years. Do not use the product after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002580

Date of registration:24.10.2011

The owner of the registration certificate:BIOCHEMIST, OJSC BIOCHEMIST, OJSC Russia

Manufacturer: & nbsp

BIOCHEMIST, OJSC Russia

Information update date: & nbsp21.08.2015

Illustrated instructions

Instructions

Papaverine (Papaverine)