Papaverine - instructions for use, dose, side effects, contraindications

Reduces the tone of smooth muscles and therefore has a vasodilating and spasmolytic effect. It is an inhibitor of the enzyme phosphodiesterase, causes intracellular accumulation of cyclic 3,5-adenosine monophosphate and a decrease in the Ca content²⁺That leads to disruption of the smooth muscle contractility and relaxation in spastic conditions papaverine action on the central nervous system is weak, but in large doses, it has some sedation.In large doses reduces the excitability of the heart muscle and slows intracardiac conduction.

Pharmacokinetics:It penetrates through the histohematological barriers. The connection with proteins is 90%. Metabolised in the liver. The half-life is 0.5-2 hours. It is excreted by the kidneys (in the form of metabolites). It is in hemodialysis.

Indications:

Spasms of smooth muscles of the abdominal cavity organs, bronchi, peripheral vessels and vessels of the brain, urinary tract, renal colic. It is used as an aid for premedication.

Contraindications:

Comatose state, respiratory depression, violation of atrioventricular conduction, glaucoma, severe hepatic insufficiency, elderly age (risk of hyperthermia), children under 6 months of age, hypersensitivity to the drug components.

Carefully:

Condition after craniocerebral trauma, chronic renal failure, insufficiency of adrenal function, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.

Pregnancy and lactation:In pregnancy and lactation, the safety of the drug is not established.

Dosing and Administration:

The drug is administered intramuscularly, subcutaneously or intravenously. A single dose for adults is 0.02-0.04 g (1-2 ml of a 2% solution); the interval between administrations is not less than 4 hours. Intravenous administration is made by diluting a 2% solution of the drug 10 - 20 ml isotonic sodium chloride solution. For elderly patients, the initial single dose should not exceed 0.01 g. For children aged 6 months to 12 years, the maximum single dose is 0.3 mg / kg body weight.

Side effects:

Allergic reactions, atrio-ventricular blockade, ventricular extrasystole, drowsiness, headache, nausea, constipation, increased sweating, lowering of arterial pressure, constipation, increased activity of "liver" transaminases, eosinophilia; redness, swelling, or pain at the injection site.

Overdose:

Symptoms: diplopia, weakness, lowering blood pressure, drowsiness.

Treatment: symptomatic (maintenance of arterial pressure).

Interaction:

Papaverine hydrochloride reduces the antiparkinsonian effect of levodopa. In combination with barbiturates, the spasmolytic effect of papaverine hydrochloride is enhanced.When combined with tricyclic antidepressants, procainamide, reserpine, quinidine sulfate, hypotensive effect may be enhanced.

Special instructions:

Intravenously, the drug should be administered slowly and under the supervision of a doctor. During the treatment period, alcohol intake should be excluded.

In pregnancy and lactation, the safety of the drug is not established.

The vasodilating effect is reduced by smoking.

Effect on the ability to drive transp. cf. and fur:

Form release / dosage:Solution for injection 20 mg / ml.

Packaging:

2 ml per ampoule of glass.

10 ampoules with a knife for opening ampoules and instructions for use are placed in a cardboard box.

10 ampoules in a blister pack.

One blister pack with a knife for opening ampoules and instructions for use is placed in a pack of cardboard.

In case of using ampoules with a break ring or a notch and a break point, the insertion of the knife for opening ampoules is not provided.

Storage conditions:

List B. At a temperature of no higher than 25 ° C, in a place protected from light and inaccessible to children.

Shelf life:

2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-000578

Date of registration:07.06.2010

The owner of the registration certificate:BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Manufacturer: & nbsp

BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Representation: & nbspBORISOVSKIY FACTORY OF MEDPREPARATES, OJSCBORISOVSKIY FACTORY OF MEDPREPARATES, OJSC

Information update date: & nbsp21.08.2015

Illustrated instructions

Instructions

Papaverine (Papaverine)