Active substancePapaverinePapaverine Similar drugsTo uncover Papaverine solution w / m in / in PC GROTEKS, LLC Russia Papaverine solution w / m in / in PC VEROPHARM SA Russia Papaverine solution w / m in / in PC BIOCHEMIST, OJSC Russia Papaverine pills inwards PHARMSTANDART-TOMSKHIMFARM, OJSC Russia Papaverine pills inwards AVEKSIMA, JSC Russia Papaverine solution w / m in / in PC BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus Papaverine suppositories rect. BIOCHEMIST, OJSC Russia Papaverine solution w / m in / in PC BIOSINTEZ, PAO Russia Papaverine pills inwards BIOSINTEZ, PAO Russia Papaverine suppositories rect. NIZHFARM, JSC Russia Papaverine solution w / m in / in PC NOVOSIBHIMFARM, OJSC Russia Papaverine solution for injections ELLARA, LTD. Russia Papaverine suppositories rect. TULA PHARMACEUTICAL FACTORY, LTD. Russia Papaverine Beefus solution w / m in / in UPDATE OF PFC, CJSC Russia Papaverine hydrochloride solution w / m in / in PC ATOLL, LLC Russia Papaverine hydrochloride solution w / m in / in PC SLAVYANSKAYA APTEKA, LLC Russia Papaverine hydrochloride solution w / m in / in PC DALHIMFARM, OJSC Russia Papaverine hydrochloride suppositories rect. BIOSINTEZ, PAO Russia Papaverine hydrochloride solution w / m in / in PC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia Papaverine hydrochloride solution w / m in / in PC Armavir Biofactory, FKP Russia Papaverine hydrochloride suppositories rect. DALHIMFARM, OJSC Russia Papaverine hydrochloride MS pills inwards MEDISORB, CJSC Russia Dosage form: & nbsprectal suppositories Composition:One suppository contains: papaverine hydrochloride - 20 mg, suppository bases: solid fat (vitepsol, supposir) - a sufficient amount until a suppository with a mass of 1.25 g is obtained. Description:Suppositories from white to white with a yellowish or creamy hue of color, torpedo shape. The appearance of a white coating on the surface of the suppository is allowed. Pharmacotherapeutic group:Spasmolytic agent. ATX: & nbspA.03.A.D Papaverine and its derivativesA.03.A.D.01 Papaverine Pharmacodynamics:Papaverine hydrochloride is a myotropic antispasmodic. Inhibits phosphodiesterase, causes accumulation in the cell of cyclic 3,5-AMP and a decrease in the calcium content. Relaxes the smooth muscles of internal organs (gastrointestinal tract, airways, urogenital system) and vessels. In large doses reduces the excitability of the heart muscle and slows intracardiac conduction. Indications:Spasm of smooth muscles: abdominal cavity organs (with cholecystitis, pilorospasm, spastic colitis, renal colic); peripheral vessels (with endarteritis); vessels of the brain (with migraine); heart (with angina pectoris - as part of complex therapy); bronchi (with bronchospasm). Contraindications:Hypersensitivity to the components of the drug, atrioventricular blockade, glaucoma, severe hepatic insufficiency, elderly age (risk of hyperthermia), children's age (up to 6 months). Carefully:Carefully (in small doses) are used in conditions after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states. Pregnancy and lactation:In pregnancy and lactation, the safety of the drug is not established. Dosing and Administration:After releasing the suppository from the contoured package, it is injected into the anus. Apply 1 suppository 2-3 times a day after spontaneous emptying of the intestine or cleansing enema. Side effects:There are allergic reactions, atrioventricular block, ventricular extrasystole, increased activity of "hepatic" transaminases, hypotension, drowsiness, constipation, eosinophilia. Overdose:Symptoms: diplopia, weakness, lowering blood pressure, drowsiness.Treatment: symptomatic (maintenance of arterial pressure). Interaction:Papaverin reduces the antiparkinsonian effect of levodopa and the hypotensive effect of methyldopa. In combination with barbiturates, the spasmolytic effect of papaverine is enhanced. When combined with tricyclic antidepressants, procainamide, reserpine, quinidine sulfate, an increase in the hypotensive effect is possible. Special instructions:The intake of ethanol should be excluded during the treatment with the drug. In pregnancy and lactation, the safety of the drug is not established. The vasodilating effect is reduced by smoking. Form release / dosage:Suppositories rectal 20 mg. Packaging:5 suppositories per contour cell pack of polyvinylchloride film, two contoured cell packs together with instructions for medical use of the drug in a cardboard bundle. Storage conditions:In a dry, protected from light at a temperature of no higher than 25 ° C. Keep out of the reach of children. Shelf life:2 years. Do not use the product after the expiry date printed on the package. Terms of leave from pharmacies:Without recipe Registration number:P N001990 / 01 Date of registration:12.02.2008 The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia Manufacturer: & nbspNIZHFARM, JSC Russia Information update date: & nbsp22.08.2015 Illustrated instructions × Illustrated instructions Instructions