Papaverine hydrochloride - instructions for use, dose, side effects, contraindications

Auxiliary substances: bases for suppositories (emulsifier No. 1, cosmetic stearin, solid fat) - a sufficient amount to produce a suppository with a mass of 1.25 g.

Description:

Suppositories from white to white with a yellowish or creamy hue of color, torpedo shape.

Pharmacotherapeutic group:Spasmolytic agent.

ATX: & nbsp

A.03.A.D Papaverine and its derivatives

A.03.A.D.01 Papaverine

Pharmacodynamics:

Spasmolytic agent, has antihypertensive effect. Inhibits PDE, causes accumulation of cAMP in the cell and a decrease in the content of Ca2 +; reduces tone and relaxes the smooth muscles of the internal organs (gastrointestinal tract, respiratory and genitourinary system) and vessels. In large doses reduces the excitability of the heart muscle and slows intracardiac conduction.The effect on the central nervous system is poorly expressed (in large doses a sedative effect is exerted).

Pharmacokinetics:Bioavailability on average - 54%. Connection with plasma proteins - 90 %. Well distributed, penetrates through the histohematological barriers. Metabolised in the liver. T1 / 2 - 0,5-2 hours (can extend up to 24 hours). It is excreted by the kidneys in the form of metabolites. Completely removed from the blood during hemodialysis.

Indications:

Spasm of smooth muscles: abdominal cavity organs (cholecystitis, pilorospasm, spastic colitis, renal colic); peripheral vessels (endarteritis); vessels of the brain; heart - angina (as part of complex therapy); bronchospasm.

Contraindications:

Hypersensitivity, AV blockade, glaucoma, severe hepatic insufficiency, elderly age (risk of hyperthermia development), children's age.

Carefully:

Conditions after traumatic brain injury, chronic renal failure, insufficiency of adrenal function, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.

Pregnancy and lactation:In pregnancy and lactation, the safety of the drug is not established.

Dosing and Administration:

Rectally, adults 20-40 mg 2-3 times a day.

Side effects:

Allergic reactions; AV blockade, ventricular extrasystole, decreased blood pressure, constipation, drowsiness, increased activity of "hepatic" transaminases, eosinophilia.

Overdose:

Symptoms: diplopia, weakness, decreased blood pressure, drowsiness.

Treatment: symptomatic (maintenance of blood pressure).

Interaction:

Papaverine hydrochloride reduces the antiparkinsonian effect of levodopa and the hypotensive effect of methyldopa.

In combination with barbiturates, the spasmolytic effect of papaverine hydrochloride is enhanced.

When combined with tricyclic antidepressants, procainamide, reserpine, quinidine, hypotensive effect of papaverine hydrochloride is possible.

Special instructions:

AT period treatment of ethanol should be excluded.

In pregnancy and lactation, the safety of the drug is not established.

The vasodilating effect is reduced by smoking.

Form release / dosage:

Suppositories rectal 20 mg.

Packaging:

5 suppositories are placed in a contour mesh package made of a polyvinyl chloride film.

2 contour packs along with the instructions for use are placed in a pack of cardboard.

Storage conditions:

In a dry place, protected from light, out of reach of children, at a temperature not exceeding 15 ° С.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N001069 / 03

Date of registration:03.12.2008

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp22.08.2015

Illustrated instructions

Instructions

Papaverine hydrochloride (Papaverine hydrochloride)