Papaverine - instructions for use, dose, side effects, contraindications

It is an inhibitor of the enzyme phosphodiesterase and causes intracellular accumulation of cyclic 3 ', 5'-adenosine monophosphate and a decrease in the calcium content, which leads to a violation of smooth muscle contractility and relaxation.

The effect of papaverine hydrochloride on the central nervous system is poorly expressed, but it has a sedative effect only in large doses.

Reduces the tone of the smooth muscles of the internal organs (gastrointestinal tract, airways, urogenital system) and vessels and therefore has a vasodilating and spasmolytic effect.

In large doses reduces the excitability of the heart muscle and slows intracardiac conduction.

Indications:

Spasm of smooth muscles: abdominal cavity organs (with cholecystitis, pilorospasm, spastic colitis, attacks of cholelithiasis), renal colic, urinary tract spasm; peripheral vessels (with endarteritis); vessels of the brain (with migraine); heart (with angina pectoris) - as part of complex therapy); bronchi (with bronchospasm).

Contraindications:

Hypersensitivity to the components of the drug, atrioventricular (AV) blockade, glaucoma, severe renal failure, severe hepatic insufficiency, elderly age (risk of hyperthermia), children's age.

Carefully:

Carefully (in small doses) are used for the condition after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.

Pregnancy and lactation:

During pregnancy and lactation, the drug should be used when the benefit to the mother exceeds the potential risk to the fetus or child.

It is recommended to suspend breastfeeding during the treatment with the drug.

Dosing and Administration:

Rectally. The suppository is injected into the anus (after cleansing enema or spontaneous bowel movement), having previously released the candle from the contour pack using scissors (cutting the package along the contour of the candle). Apply 1-2 suppository 2-3 times a day.

Side effects:

Possible allergic reactions, partial or complete atrioventikuryarnaya blockade, ventricular ekstrasistoliya, lowering blood pressure, increasing the activity of "liver" transaminases. hypotension, drowsiness, constipation, eosinophilia.

Inform your doctor about any unwanted or unpleasant reactions and sensations.

Overdose:

Symptoms: diplopia, weakness, lowering of blood pressure, drowsiness.

Treatment: symptomatic (maintenance of arterial pressure).

Interaction:

Papaverine reduces the antiparkinsonian effect levodopa and hypotensive effect methyldopy.

In combination with barbiturates The spasmolytic effect of papaverine is enhanced.

When combined with tricyclic antidepressants, procainamide, reserpine, quinidine sulfate possibly strengthening the hypotensive effect.

Special instructions:

The intake of ethanol should be excluded during the treatment with the drug.

The vasodilating effect is reduced by smoking.

Effect on the ability to drive transp. cf. and fur:

During the treatment with the drug should refrain from driving and other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Suppositories rectal, 20 mg.

Packaging:

Suppositories of 5 each in blisters of a bilayer film of aluminum-polyethylene; 2 contour mesh packages together with instructions for medical use of the drug are placed in a cardboard box.

Storage conditions:

In a place protected from moisture and light, at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date indicated on the label.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003815

Date of registration:31.08.2016

Expiration Date:31.08.2021

The owner of the registration certificate:TULA PHARMACEUTICAL FACTORY, LTD. TULA PHARMACEUTICAL FACTORY, LTD. Russia

Manufacturer: & nbsp

TULA PHARMACEUTICAL FACTORY, LTD. Russia

Representation: & nbspTULA PHARMACEUTICAL FACTORY, LTD.TULA PHARMACEUTICAL FACTORY, LTD.

Information update date: & nbsp16.10.2016

Illustrated instructions

Instructions

Papaverine (Papaverine)