Papaverine hydrochloride MS - instructions for use, dose, side effects, contraindications

Spasmolytic agent, has antihypertensive effect. Inhibits phosphodiesterase, causes accumulation in the cell of cyclo-adenosine monophosphate and a decrease in the content of Ca²⁺; reduces tone and relaxes the smooth muscles of the internal organs (gastrointestinal tract, respiratory and genitourinary system) and vessels. In large doses reduces the excitability of the heart muscle and slows intracardiac conduction. The effects on the central nervous system are poorly expressed (in large doses a sedative effect is exerted).

Pharmacokinetics:

Absorption depends on the dosage form. Bioavailability on average - 54%. Communication with plasma proteins is 90%. Well distributed, penetrates through histohematological. barriers. Metabolised in the liver. The half-life is 0.5-2 hours (may extend up to 24 hours). It is excreted by the kidneys in the form of metabolites. Completely removed from the blood during hemodialysis.

Indications:

Papaverine is used for spasms of smooth muscles:

- Abdominal cavity organs (cholecystitis, pilorospasm, spastic colitis, renal colic);

- peripheral vessels (endarteritis);

- vessels of the brain;

- heart vessels;

- Angina pectoris (as part of complex therapy);

- bronchospasm.

As an auxiliary medicine for premedication.

Contraindications:

hypersensitivity;

- atrioventricular block;

- glaucoma;

severe hepatic impairment;

- Old age (risk of hyperthermia);

- Children's age (up to ten years).

Carefully:

Caution is prescribed to patients after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock conditions.In pregnancy and lactation, the safety of the drug is not established.

Dosing and Administration:

Papaverine is taken orally 40-60 mg 3-4 times a day (adults). The highest single dose is 200 mg, the daily dose is 600 mg.

Children aged 10-14 years - 20 mg (1/2 pills).

Side effects:

From the skin: allergic reactions.

Co side of the digestive tract: constipation, increased activity of "liver" transaminases.

From the side of the cardiovascular system: atrioventricular blockade, ventricular extrasystole, lowering of arterial pressure.

On the part of the hematopoiesis system: eosinophilia.

From the central nervous system: drowsiness.

Overdose:

Symptoms of overdose: diplopia, weakness, lowering of blood pressure, drowsiness.

Treatment: symptomatic (maintenance of arterial pressure).

Interaction:

maybe gain hypotensive effect of papaverine when combined with tricyclic antidepressants, procainamide, reserpine, quinidine.

Spasmolytic action papaverine intensified when used simultaneously with barbiturates

With simultaneous applications papaverine reduces antiparkinsonian effect of levodopa and hypotensive effect of methyldopa.

Special instructions:

During the treatment period, ethanol intake should be excluded.

The vasodilating effect of the drug is reduced by smoking.

Form release / dosage:

Tablets of 40 mg in a package of 10 pieces.

Packaging:

For 10 tablets in a contour non-jammed package of paper with a polymer coating.

For 10 tablets in a contoured cell pack of a polyvinyl chloride film and aluminum foil printed lacquered or paper with a polymer coating.

1, 2, 3, 5, 10 contour non-jaw or cell packs with instructions for use are placed in a bundle.

Contoured packages, together with an equal number of instructions for use, are placed in a group package.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C. In a place inaccessible to children.

Shelf life:

5 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N001606 / 01

Date of registration:27.01.2009

The owner of the registration certificate:MEDISORB, CJSC MEDISORB, CJSC Russia

Manufacturer: & nbsp

MEDISORB, CJSC Russia

Information update date: & nbsp21.08.2015

Illustrated instructions

Instructions

Papaverine hydrochloride MS (Papaverine hydrochloride MS)