Papaverine - instructions for use, dose, side effects, contraindications

Papaverin lowers the tone of smooth muscles and therefore has a vasodilating, spasmolytic and hypotensive effect. It is an inhibitor of the enzyme phosphodiesterase and causes intracellular accumulation of cAMP and a decrease in the level of calcium ions, which leads to a violation of contractility of smooth muscles and their relaxation during spastic conditions. The effect of papaverine on the central nervous system is poorly expressed, only in large doses it has some sedative effect.In large doses reduces the excitability of the heart muscle and slows intracardiac conduction.

Pharmacokinetics:

The connection with plasma proteins is 90%. Easily passes through the histohematological barriers, in the liver undergoes biotransformation. The half-life is 0.5-2 hours (may extend up to 24 hours). It is excreted by the kidneys mainly in the form of metabolites. Completely removed from the blood during hemodialysis.

Indications:Spasm of smooth muscles of the abdominal cavity organs (cholecystitis, pilorospasm, spastic colitis), peripheral vessels (endarteritis), cerebral vessels, heart - angina (as part of complex therapy); renal colic, bronchospasm. It is used as an aid for premedication.

Contraindications:

Comatose state, respiratory depression, violation of atrioventricular conduction, severe hepatic insufficiency, glaucoma, elderly age (risk of hyperthermia), children's age (up to 6 months), hypersensitivity to the components of the drug.

Carefully:

Conditions after traumatic brain injuries, chronic renal failure, insufficiency of adrenal function, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.

Pregnancy and lactation:

During pregnancy and lactation, the safety of the drug is not established.

Dosing and Administration:

The drug is administered intramuscularly, subcutaneously or intravenously. A single dose for adults is 0.02-0.04 g (1-2 ml of 2 mg / ml solution), the interval between administrations is at least 4 hours. Intravenous administration is made by first diluting the 2 mg / ml solution of the preparation with 10-20 ml of isotonic sodium chloride solution. For elderly patients, the initial single dose should not exceed 0.01 g. For children aged 6 months to 12 years, the maximum single dose is 0.3 mg / kg body weight.

Side effects:

With rapid intravenous administration, it is possible to develop atrioventricular blockade, ventricular extrasystole, and lowering blood pressure (BP). Possible drowsiness, headache, nausea, constipation, increased sweating, increased activity of "liver" transaminases, eosinophilia.

Allergic reactions to the components that make up the drug.

Overdose:

Symptoms: impaired vision (diplopia), weakness, decreased blood pressure, drowsiness. Treatment: symptomatic (maintenance of blood pressure).

Interaction:

Papaverin reduces the antiparkinsonian effect of levodopa and the hypotensive effect of methyldopa. In combination with barbiturates, the spasmolytic effect of papaverine is enhanced. When combined with tricyclic antidepressants, procainamide, reserpine, quinidine, an increase in the hypotensive effect is possible.

Special instructions:

Intravenously, the drug should be administered slowly and under the supervision of a doctor.

During the treatment period, alcohol intake should be excluded.

The vasodilating effect is reduced by smoking.

Effect on the ability to drive transp. cf. and fur:No information.

Form release / dosage:

Solution for injection 20 mg / ml.

Packaging:

2 ml per ampoule of neutral glass.

For 10 ampoules with instructions for use and a knife for opening ampoules or a scarifier ampoule in a box of cardboard.

By 5 or 10 ampoules per contour cell packaging of polyvinyl chloride film or polyethylene terephthalate and aluminum foil or paper with polyethylene coating or without foil, or without paper.

For 1 or 2 contour squares with instructions for use and a knife for opening ampoules or a scarifier ampullum is placed in a pack of cardboard.

When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper is not put in.

Storage conditions:

Store in a dark place at a temperature of 15 to 25 ° C. Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002103 / 01

Date of registration:26.11.2007

The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia

Manufacturer: & nbsp

NOVOSIBHIMFARM, OJSC Russia

Information update date: & nbsp22.08.2015

Illustrated instructions

Instructions

Papaverine (Papaverine)