Active substanceTroxerutinTroxerutin
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  • Dosage form: & nbspgel for external use
    Composition:

    Composition (for 40 g):

    active substance: troxerutin - 0,800 g.

    Excipients: carbomep 940 (0.240 g), disodium edetate (0.020 g) of benzalkonium chloride (0.023 g), sodium hydroxide (0.084 g), purified water (38.833 g).

    Description:homogeneous yellow gel
    Pharmacotherapeutic group:angioprotective agent
    ATX: & nbsp

    C.05.C.A   Bioflavonoids

    C.05.C.A.04   Troxerutin

    Pharmacodynamics:

    Flanovoid (derivative of routine), has P-vitamin activity; renders, venotonic, angioprotective, anti-inflammatory and decongestant effect.

    Its pharmacodynamic properties are associated with the participation of trouxerutin bioflavonoids in oxidation-reduction processes and inhibition of hyaluronidase. Inhibiting hyaluronidase, troxerutin stabilizes hyaluronic acid of cell membranes and reduces permeability and fragility of capillaries, increases their tone. It has antioxidant activity, which prevents oxidation of ascorbic acid, adrenaline and lipids. Prevents damage to the basement membrane of endothelial cells when exposed to various factors. Troxerutin reduces exudative inflammation in the vascular wall, limiting the adhesion of platelets to its surface. As a result of treatment trokserutinom disappears feeling of heaviness in the legs, the swelling of tissues decreases, trophic is improving.

    Pharmacokinetics:

    Troxerutin is well absorbed from the surface of the skin when applied in the form of a gel.The active substance penetrates into the blood vessels of the subcutaneous tissue. When topical application does not cause a systemic effect on the organs, since there is no significant penetration of troxerutin into the general circulation.

    Indications:

    - Chronic venous insufficiency;

    - Phlebeurysm;

    - Surface thrombophlebitis, periphlebitis and phlebothrombosis;

    - Post-traumatic swelling of soft tissues, hematoma;

    - Post-thrombotic syndrome.

    Contraindications:

    - Hypersensitivity to troxerutin or any other auxiliary substance gel.

    - Children under 18 years.

    Pregnancy and lactation:

    Pregnancy

    There is no evidence of adverse effects on development during the use of the drug in the first months of pregnancy, so there is no contraindication to its appointment to pregnant women.

    Breast-feeding

    There is no data on the excretion of the drug in breast milk, so troxerutin in the form of a gel can be prescribed to women during breastfeeding.

    Dosing and Administration:Outwardly.
    Adults
    The gel is applied twice a day in the morning and in the evening, gently rubbing it into affected skin with lungs massaging movements. If necessary, the gel can be apply in the form of compresses and occlusive dressings. Troxerutin Vramed gel is not is used in children.
    Side effects:When treating with troxerutin (gel), side effects are rarely observed. With prolonged use, redness of the skin and itching are possible.
    Overdose:There is no evidence of an overdose of the drug when it is applied topically.
    Interaction:There is no evidence of adverse interactions of troxerutin with other drugs.
    Special instructions:The reaction of the gel (pH) corresponds to that of the skin, so when applied externally, it does not cause irritation and hypersensitivity. The gel does not violate the normal physiological properties of the skin (passage through the pores, acid-base balance, permeability), since it is created on a water basis.
    Effect on the ability to drive transp. cf. and fur:

    The use of the drug does not affect the ability to drive vehicles and engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Gel for external use 2%.
    Packaging:

    40 g of gel in aluminum membrane tubes, with an internal lacquer coating.

    Every tuba together with the instructions for use are placed in a pack of cardboard.

    Storage conditions:

    In dry, dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children!

    Shelf life:

    5 years. Do not use after the expiration date printed on the package.

    Shelf life after the opening of the tube: up to 1 month.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N011640 / 01
    Date of registration:26.09.2011
    The owner of the registration certificate:Sopharma, AOSopharma, AO Bulgaria
    Manufacturer: & nbsp
    Representation: & nbspSOFARMA SA SOFARMA SA Bulgaria
    Information update date: & nbsp21.10.2015
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