Troxsevenol - instructions for use, dose, side effects, contraindications

auxiliary substances: Carbomer 940 - 0.6 g; disodium edetate - 0.05 g; Benzalkonium chloride - 0.0575 g; sodium hydroxide 30% -0.7 g; purified water - up to 100 g.

Description:

transparent gel from yellow to light brown or yellow-green

colors

Pharmacotherapeutic group:angioprotective agent

ATX: & nbsp

C.05.C.A Bioflavonoids

C.05.C.A.04 Troxerutin

Pharmacodynamics:

Troxsevenol is a flavonoid (derivative of routine), has P-vitamin activity; has venotonic, angioprotective, anti-edematous, antioxidant and anti-inflammatory effects.

Its pharmacodynamic properties are associated with the participation of troxerutin in the oxidation-reduction processes and inhibition of hyaluronidase. Inhibiting hyaluronidase, troxerutin stabilizes the hyaluronic acid of the cell membranes and reduces the permeability and fragility of capillaries, increases their tone. Has antioxidant activity, resulting in prevents the oxidation of ascorbic acid, adrenaline and lipids. Prevents damage to the basement membrane of endothelial cells when exposed to various factors. Troxerutin reduces exudative inflammation in the vascular wall, limiting adherence to its surface of platelets.As a result of treatment with troxerutin, the sense of heaviness in the legs disappears, the swelling of tissues decreases, and trophicity improves.

Pharmacokinetics:

When applied to the skin, the active substance quickly penetrates the epidermis, after 30 minutes it is found in the dermis, and after 2-5 hours - in the subcutaneous fatty tissue.

Indications:Varicose veins, chronic venous insufficiency accompanied by swelling, pain sensation of heaviness in the legs. Thrombophlebitis, periphlebitis, varicose dermatitis, pain and swelling after injuries (bruises, ligament damage).

Contraindications:

Damage to the integrity of the skin, hypersensitivity to trokserutinu or to any auxiliary substance of the gel.

It is not recommended to use the drug in children under the age of 18, given the lack of sufficient clinical experience.

Pregnancy and lactation:

The use of the drug is contraindicated in pregnancy (I trimester). The drug can be used in the second and third trimester of pregnancy, as well as during breastfeeding.

Dosing and Administration:

Outwardly. Column gel 4-5 cm long is applied a thin layer on the affected areas and easily rubbed 3-4 times a day.The daily dose should not exceed 20 cm of the gel. Duration of treatment - no more than 10 days. The gel can be applied under the occlusive dressing.

Features of the drug during the first admission or when it is canceled are absent.

Side effects:In rare cases, there are allergic reactions (redness of the skin, itching, rash). These symptoms quickly pass after discontinuation of treatment).

Overdose:

No data on overdose during external application.

If you accidentally swallow the drug, you may feel a burning sensation in the mouth, salivation, nausea, vomiting. In this case, washing of the mouth and stomach is indicated, if necessary, symptomatic treatment.

In contact with the eyes, mucous membranes and open wounds, local irritation is observed - lacrimation, hyperemia, burning, pain. The gel is washed off with a large amount of distilled water or isotonic sodium chloride solution until the symptoms disappear completely or significantly decrease.

Interaction:

There is no data on the interaction of the drug, in this dosage form, with other drugs.

Special instructions:Avoid getting the gel on the exposed surfaces of wounds, mucous membranes, and in the eyes.

Effect on the ability to drive transp. cf. and fur:

There is no information.

Form release / dosage:gel for external use, 2%

Packaging:

For 40 grams in aluminum tubes or tubes of combined material or laminated or in jars (bottles) of dark glass or in glass jars with a triangular aureole.

Each tube or jar (bottle), together with the instruction for use, is placed in a pack of cardboard box. It is allowed to lay tubes or jars (bottles) in a group package (carton box) with an equal number of instructions for use.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiration date indicated on the label.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001390

Date of registration:20.12.2011

The owner of the registration certificate:SAMARAHEDPROM, JSC SAMARAHEDPROM, JSC Russia

Manufacturer: & nbsp

SAMARAHEDPROM, JSC Russia

Information update date: & nbsp21.10.2015

Illustrated instructions

Instructions

Troxsevenol (Troxevenol)