From the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with liver disease), hepatitis, hepatonecrosis, pseudomembranous colitis.
From the central and peripheral nervous system: dizziness, headache, fatigue, agitation, convulsions, anxiety, tremor, insomnia, "nightmarish" dreams, peripheral paralysis (anomaly of perception of pain), sweating, increased intracranial pressure, confusion, depression,hallucinations, as well as other manifestations of psychotic reactions (occasionally progressing to conditions in which the patient can do harm to himself, with suicidal tendencies), migraine, fainting, thrombosis of the cerebral arteries.
From the sense organs: violation of taste and smell, visual impairment (diplopia, change in color perception), tinnitus, hearing loss.
From the cardiovascular system: tachycardia, heart rhythm disturbances, lowering of blood pressure (BP), sensation of "tides" of blood to the skin of the face.
From the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
From the urinary system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, decreased renal nitrogen function, interstitial nephritis.
Allergic reactions: skin itching, urticaria, the formation of blisters accompanied by bleeding and small nodules that form scabs, drug fever, pinpoint hemorrhages (petechiae),edema of the face or larynx, dyspnea, eosinophilia, vasculitis, exanthema, nodal erythema, exudative erythema multiforme, Stevens-Johnson syndrome (malignant exudative erythema), toxic epidermal necrolysis (Lyell's syndrome), anaphylactic shock.
From the musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, myalgia, edema in the joint region.
Other: general weakness, sweating, superinfections (candidiasis), increased photosensitivity
From the laboratory indicators: hypoprothrombinemia, increased activity of "liver" transaminases and alkaline phosphatase, hypercreatininaemia, hyperbilirubinemia, hyperuricemia, hyperglycemia.
Local: pain and burning at the injection site, phlebitis.