On the part of the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, decreased appetite, cholestatic jaundice (especially in patients with liver disease), hepatitis, hepatonecrosis.
From the nervous system: dizziness, headache, fatigue, anxiety, tremor, insomnia, "nightmarish" dream, peripheral paralgeziya (anomaly perception feelings of pain), increased sweating, increased intracranial pressure, confusion,depression, hallucinations, as well as other manifestations of psychotic reactions (occasionally progressing to conditions in which the patient can do harm to himself), migraine, fainting, thrombosis of the cerebral arteries.
From the senses: a violation of taste and smell, visual impairment (diplopia, change in color perception), noise in the ears, hearing loss.
Cardio-vascular system: tachycardia, cardiac arrhythmias, lowering blood pressure.
From the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
Laboratory indices: hypoprothrombinemia, increased activity of "liver" transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
From the urine of the excretory system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, decreased renal nitrogen function, interstitial nephritis.
Allergic reactions: itching, hives, blistering, accompanied by bleeding,and the appearance of small nodules that form scabs, drug fever, puncture of the face or larynx, dyspnea, eosinophilia, vasculitis, erythema nodosum, multiforme erythema exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
From the musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, myalgia.
Other: asthenia, increased photosensitivity, superinfections (candidiasis, pseudomembranous colitis), "tides" of blood to the face.