From the gastrointestinal tract: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with liver disease), hepatitis, hepatonecrosis.
From the nervous system: dizziness, headache, fatigue, anxiety, tremor, insomnia, nightmarish dreams, peripheral paralysis (anomaly of perception of pain), sweating, increased intracranial pressure, anxiety, confusion, depression, hallucinations, as well as other manifestations of psychotic reactions (occasionally progressing to conditions in which the patient can do harm to himself), migraine, fainting, thrombosis of the cerebral arteries.
From the sense organs: violation of taste and smell, visual impairment (diplopia change in color perception), tinnitus, hearing loss.
From the cardiovascular system: tachycardia, heart rhythm disturbances, lowering blood pressure, flushing of blood to the skin of the face.
From the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
Laboratory indicators: hypoprothrombinemia, increased activity of "liver" transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
From the urinary system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, hematuria, decreased renal nitrogen function, interstitial nephritis.
From the musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, myalgia.
Allergic reactions: dermal itching, urticaria, the formation of blisters accompanied by bleeding, and small nodules forming scabs, drug fever, pinpoint hemorrhages (petechiae), edema of the face and larynx, dyspnea, eosinophilia, vasculitis, nodal erythema, exudative erythema multiforme, Stevens-Johnson syndrome malignant exudative erythema), toxic epidermal necrolysis (Lyell's syndrome).
Other: increased photosensitivity, general weakness, superinfection (candidiasis, pseudomembranous colitis).