from the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, decreased appetite, cholestatic jaundice (especially in patients with liver disease), pseudomembranous colitis, hepatitis, hepatonecrosis;
from the central nervous system: dizziness, headache, fatigue, anxiety, tremor, insomnia, nightmarish dreams, peripheral paralysis (anomaly of perception of pain), increased sweating, increased intracranial pressure, confusion, depression, hallucinations, and other manifestations of psychotic reactions (occasionally progressing to the conditions in which the patient can do harm to himself), migraine, syncope, thrombosis of the cerebral arteries;
sensory organs: violation of taste and smell, visual impairment (diplopia, change in color perception), tinnitus, hearing loss;
from the urinary system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, decreased renal nitrogen function, interstitial nephritis;
from the hematopoiesis system: eosinophilia, leukopenia, neutropenia, change in the number of platelets, hemolytic anemia;
from the cardiovascular system: tachycardia, violation of the heart rhythm, arterial hypotension, "hot flashes" of blood to the skin of the face;
allergic reactions: dermal itching, urticaria, the formation of blisters accompanied by bleeding, and the appearance of small nodules that form scabs, drug fever, pinpoint hemorrhages on the skin (petechiae), edema of the face or larynx, dyspnea, eosinophilia, vasculitis, nodal erythema, multiforme exudative erythema Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), anaphylactic shock;
from the laboratory indicators: increased urea concentration, creatinine, increased activity of hepatic transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, hypoprothrombinemia;
from the musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, asthenia, myalgia;
local reactions: pain, burning at the injection site, phlebitis;
Other: superinfection (candidiasis, pseudomembranous colitis), rarely - photosensitivity, general weakness.