Korneregel - instructions for use, dose, side effects, contraindications

Pharmacodynamics:The active substance of the drug Korneregel® is dexpanthenol / panthenol, a precursor of pantothenic acid, which thus possesses all the same biological properties as D-pentothenic acid, which, having become a human body in coenzyme A, is involved in many metabolic processes. The data obtained in animal experiments indicate an increase in the proliferation of fibroblasts and the presence of a regenerating effect. With external application dexpanthenol It can compensate for the increased need for damaged skin or mucous membranes in pantothenic acid. The eye gel has a high viscosity, which allows long-term contact of dexpanthenol with the surface of the mucous membrane of the eye.

Pharmacokinetics:

Based on the results of studies of tritiated dexpanthenol, its penetration (adsorption) through the skin has been established.

To increase the duration of contact of an aqueous solution of dexpanthenol with the epithelium of the cornea, the composition of the drug Korneregel® contains carbomer, which because of high molecular weight does not penetrate into the tissues of the eyeball and is not absorbed into the systemic bloodstream.

Indications:

- Treatment of non-inflammatory keratopathy, for example, such as: corneal dystrophy, recurrent erosion, corneal damage when wearing contact lenses;

- as an auxiliary therapy to stimulate the healing process of the cornea and conjunctiva in their injuries and burns (chemical and thermal);

- an auxiliary agent in the treatment of infectious lesions of the cornea of bacterial, viral or fungal origin.

Contraindications:

Individual hypersensitivity to any of the components of the drug.

Carefully:

During pregnancy and during breastfeeding (no clinical data are available).

Pregnancy and lactation:

Data on the effects of pantothenic acid on ingestion during pregnancy and the development of the fetus or the health of the newborn are not available.However, it is known that when ingested pantothenic acid, which it metabolizes dexpanthenol, freely penetrates the placenta and is excreted through breast milk in proportion to the amount of the drug taken.

Since there is no data on the concentration of dexpanthenol (pantothenic acid) in the blood plasma after topical application in the form of an eye gel, the use of Korneregel® during pregnancy and / or breastfeeding is possible only after consulting a doctor when the expected benefit to the mother exceeds the potential risk to the fetus and / or child.

Dosing and Administration:

Locally.

In the lower conjunctival sac of the affected eye, 1 drop 4 times a day, as well as 1 drop before going to bed.

Side effects:

Itching, hyperemia, conjunctival edema, pain, sensation of "foreign body", increased tearing, transient "blurring" of vision.

Allergic reactions: rarely - increased sensitivity (itching, rashes on the skin.

Overdose:

Data on drug overdose are absent.

Interaction:

Cases of incompatibility with other drugs are unknown.

In cases where additional local therapy with eye drops / ointments is being carried out, the interval between the administration of Korneregel® and other ophthalmic preparations should be at least 15 minutes.

Due to their physical properties, the Korneregel® preparation can prolong the residence time of other ophthalmic drugs in the eye and thereby enhance their effect. Therefore, Korneregel® should be used last.

Special instructions:

Corneregel® should not be used as a monotherapy for infectious damage to the cornea of a bacterial, viral or fungal origin.

Preservative cetrimide, which is part of the drug, can cause local eye irritation, allergic reactions (burning, redness, sensation of the "foreign body" in the eye) and damage to the corneal epithelium with prolonged or too frequent use.

During the treatment with Korneregel®, contact lenses should not be worn because of the possible incompatibility of the drug with lens material. However, if contact lenses are still indicated, before using Korneregel®, they should be removed and re-put no earlier than 15 minutes after instillation of the drug.

Do not touch the tip of the pipette tube to the eye.

The tube must be closed after each use.

If no improvement is noted, signs of eye irritation appear, discontinue use of the drug and seek medical advice.

Effect on the ability to drive transp. cf. and fur:

After instillation of the drug on the cornea, a thin film forms, which can cause a brief "clouding" of the vision, thereby reducing the reaction rate. Therefore, the management of vehicles and mechanisms should proceed, when the clarity of vision is restored.

Form release / dosage:

Eye gel, 5%.

Packaging:

For 5 g or 10 g in tubes with a head with a nozzle and a screw cap made of PVP.

1 Tuba with instructions for medical use in a cardboard box.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 of the year.

After opening the tube, store it for no more than 6 weeks.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N015841 / 01

Date of registration:30.09.2009 / 01.12.2014

Expiration Date:Unlimited

The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia

Manufacturer: & nbsp

Dr. GERHARD MANN Chem.-Pharm. Fabrik, GmbH Germany

Representation: & nbspVALEANT LLC VALEANT LLC Russia

Information update date: & nbsp04.02.2018

Illustrated instructions

Instructions

Correregel® (Corneregel®)