Intravenously. The daily dose is 30-160 mg / kg (3-12 g / day), the frequency of administration is 2-4 times a day. Parenteral administration of piracetam is given if oral administration of the drug is not possible, for example, with difficulty swallowing, or when the patient is in a coma.
The solution of Lutzamam is compatible with the following infusion solutions:
| Glucose | 5%, 10%, 20% |
| Fructose | 5%, 10%, 20% |
| Levulose | 5% |
| Sodium chloride | 0,9 % |
| Dextran 40 | 10% in a 0.9% solution of sodium chloride |
| Dextran 100 | 6% in a 0.9% solution of sodium chloride |
| Ringer's solution
Mannitol-Dextran
Hydroxyethyl starch | 6% |
Infusion solutions with the addition of pyracetam are stable for at least 24 hours.
Dosage regimen
Adults
Symptomatic treatment of psycho-organic syndrome:
With symptomatic treatment of chronic psychoorganic syndrome, depending on the severity of the symptoms, 2.4-4.8 g per day are prescribed, spreading over 2-3 injections.
Treatment of dizziness and related disorders of equilibrium:
2.4 - 4.8 g per day, divided into 2-3 injections.
Cortical myoclonia:
Treatment begins with 7.2 g / day, every 3-4 days the dose increases by 4.8 g / day until the maximum dose of 24 g / day. Later on they switch to the oral form of Lucetam. Treatment continues throughout the period of the disease. To prevent the deterioration of patients, the drug should not be discontinued drastically. It is necessary to gradually reduce the dose of the drug. In the absence of effect or the presence of a slight therapeutic effect, treatment is discontinued.
Closing (parenteral) sickle-cell vaso-occlusive crisis:
The drug is used in a dose of 300 mg / kg of body weight, dividing into 4 doses
Children and teens
As part of the complex therapy of dyslexia in children aged 8 years:
The daily dose is 3.2 g, divided into 2 injections
Killing of sickle-cell vaso-occlusive crisis in children over 3 years of age:
300 mg / kg body weight, divided into 4 receptions.
Dosing to patients with impaired renal function:
Because the piracetam is excreted from the body by the kidneys, care should be taken when treating patients with renal insufficiency in accordance with the above schemedosing.
Calculation of the dose should be based on an assessment of the creatinine clearance in the patient. Which is calculated by the formula:
TOcr= [140-year (in years) *m (in kg)] / [72 * with creatinine in plasma (mg / dL)]
For women: Kcr*0,85.
Prescribe treatment to such patients, depending on the severity of renal failure, adhering to the following recommendations:
| Renal failure | Creatinine clearance (ml / min) | Dosing |
| Norm | >80 | Usual Dose |
| Lightweight | 50-79 | 2/3 of the usual dose in 2 to 3 doses |
| Average | 30-49 | 1/3 of the usual dose in 2 divided doses |
| Heavy | <30 | 1/6 of the usual dose, once |
| The final stage | <20 | contraindicated |
Dosing to elderly patients:
Elderly, the dose is corrected in the presence of renal failure and with prolonged therapy requires monitoring of kidney function.
Dosing to patients with impaired liver function:
Patients with a dysfunction of the liver do not need a dose adjustment. Patients with impaired functions and kidneys and liver, dosing is carried out according to the scheme (see Section "Dosing to patients with impaired renal function")