Pyracetam - instructions for use, dose, side effects, contraindications

Other auxiliary substances: silicon colloidal dioxide, gelatin, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate, titanium dioxide, dye yellow, dye Ponso 4 R, dye brilliant blue, dye azorubin.

Description:Hard gelatin capsules, the lid of which is painted black, and the body - in red. Capsules contain a white or almost white powder. The size of capsules number 1.

Pharmacotherapeutic group:Nootropic agent.

ATX: & nbsp

N.06.B.X.03 Pyracetam

Pharmacodynamics:

It has a positive effect on brain metabolic processes, increases the concentration of ATP in the brain tissue, enhances the biosynthesis of ribonucleic acid and phospholipids, stimulates glycolytic processes, and enhances the utilization of glucose. It improves the integrative activity of the brain, facilitates the consolidation of memory, facilitates the learning process. Changes the speed of propagation of excitation in the brain, improves microcirculation, without providing a vasodilating action, inhibits the aggregation of activated platelets. Has a protective effect in brain damage caused by hypoxia, intoxication, electroshock, increases alpha and beta activity, reduces delta activity on the EEG, reduces the severity of the vestibular nystagmus. Has no sedative, psycho-stimulating effect. The drug improves the connections between the cerebral hemispheres and synaptic conductivity in neocortical structures, restores and stabilizes cerebral functions, especially consciousness, memory and speech, increases mental performance, improves cerebral blood flow.

Pharmacokinetics:

After ingestion, it is well absorbed and penetrates into various organs and tissues. Bioavailability, regardless of the dosage form, is about 95%. TS_max - 0.5-1 hours Penetrates through blood-brain and placental barriers, accumulates in the brain tissue 1-4 h after ingestion. From the cerebrospinal fluid is derived much slower than from other tissues. Virtually not metabolized. T_1/2 - 4.5 hours (7.7 hours - from the brain). It is excreted by the kidneys - 2/3 unchanged for 30 hours.

Indications:

The drug is used in neurological, psychiatric and narcological practice.

Neurology: cerebrovascular diseases (atherosclerosis, hypertension, vascular parkinsonism) with the phenomena of chronic cerebrovascular insufficiency (memory, attention, speech, dizziness, headache); disorders of cerebral circulation; comatose states, the consequences of injuries and brain intoxication in order to increase motor and mental activity. Diseases of the nervous system, accompanied by a decrease in intellectual-mnestic functions and disorders of the emotional-volitional sphere; symptomatic treatment in patients with Alzheimer's disease and senile dementia of the Alzheimer type.

Psychiatry: neurotic and astheno-dynamic depressive states of various genesis with prevalence in the clinical picture of the signs of adynamia, asthenic and senesto-hypochondriacal disorders, phenomena of ideational inhibition; sluggish-apathetic defective conditions in schizophrenia, psychoorganic syndromes of various etiology, senile and atrophic processes; complex therapy of mental illnesses occurring on "organically inferior soil". Complex therapy of depressive conditions resistant to antidepressants; poor tolerability of neuroleptics and other psychotropic agents with the aim of eliminating or preventing the somato-vegetative, neurological and psychiatric complications caused by them; epilepsy.

Narcology: relief of abstinent, pre- and delirious states with alcoholism, drug addiction, in case of acute alcohol poisoning, morphine, barbiturates, phenamine; chronic alcoholism with the phenomena of persistent mental disorders (asthenia, intellectual-mnestic disorders).

In the complex therapy of sickle-cell anemia.

Pediatrics: If necessary, accelerate the learning process and eliminate the consequences of perinatal brain damage, with oligophrenia, mental retardation, cerebral palsy.

Contraindications:

Hypersensitivity, renal insufficiency (creatinine clearance less than 20 ml / min), pregnancy, lactation, children's age (up to 1 year), hemorrhagic stroke (acute stage), depression with anxiety (agitated depression), Huntington's chorea.

Carefully:

In the treatment of acute brain damage piracetam prescribe in conjunction with other methods of detoxification and restorative therapy, in the treatment of psychotic conditions - with psychotropic drugs. It is recommended that the kidney function be monitored continuously. In the treatment of patients with cortical myoclonia, abrupt withdrawal of the drug should be avoided (risk of resumption of seizures). In case of occurrence of disturbances of a dream it is recommended to cancel an evening reception, having added this dose to a day reception. With caution appoint in patients with hemostasis disorder, after extensive surgical interventions, severe bleeding.

Dosing and Administration:

Inside at the beginning of treatment appoint 800 mg in 3 doses before meals, with the improvement of the condition, a single dose is gradually reduced to 400 mg. The daily dose is 30-160 mg / kg of body weight, the frequency of intake is 2 times / day, if necessary 3-4 times / day. The course of treatment continues from 2-3 weeks to 2-6 months. If necessary, repeat the treatment. With prolonged therapy of psychoorganic syndrome in elderly patients, the drug is prescribed at 1.2-2.4 g / day; The loading dose for the first weeks of therapy is up to 4.8 g / day. Treatment with pyracetamol, if necessary, can be combined with the use of psychotropic, cardiovascular and other drugs.

When treating the aftermath of coma, in the post-traumatic period the initial dose is 9-12 g / day, the support dose is 2.4 g, the course of treatment is 3 weeks.

This dosage form is recommended for children from 5 years - 1 capsule 3 times a day. The maximum daily dose is -1.8 g. The course of treatment is from 2 weeks to 2-6 months.

At alcoholism - 12 g / day during the manifestation of alcohol withdrawal syndrome; maintenance dose - 2.4 g.

In sickle cell anemia, the daily dose is 160 mg / kg body weight divided into 4 equal portions

Attention, the last single dose should be taken no later than 5 pm to prevent sleep disturbances.

Side effects:

Side effects are most often noted at doses above 5 g / day. Nervousness, agitation, irritability, restlessness, sleep disorder, gastralgia, nausea, vomiting, diarrhea, constipation, anorexia, dizziness, headache, extrapyramidal disorders, convulsions, trembling, increased sexual activity; rarely - weakness, drowsiness; in the elderly, there is an increase in anginal attacks. In children, especially with mental retardation: fussiness, anxiety, restlessness, motor disinhibition, decreased ability to concentrate, unbalanced, irritable, increased conflict.

Overdose:

There may be an increase in possible side effects. First aid - washing the stomach, taking activated carbon.

Interaction:

Increases the effectiveness of thyroid hormones, indirect anticoagulants (against a background of high doses of pyracetam), psychostimulants. When administered with neuroleptics reduces the risk of extrapyramidal disorders. With simultaneous admission with neuroleptics, their central effect (tremor, restlessness, etc.) increases.

Special instructions:

When taking piracetam, periodic monitoring of the indicators of kidney function is recommended, and in patients with liver diseases - the functional state of the liver.

In the treatment of patients with cortical myoclonia, abrupt withdrawal of the drug should be avoided (risk of resumption of seizures)

Effect on the ability to drive transp. cf. and fur:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Capsules of 400 mg.

Packaging:

For 10,15,20 capsules in a blister, 1,2,3,4,5,6,10 blisters together with instructions for use are placed in a cardboard box.

Storage conditions:

List B. In a dry place, inaccessible to children, at a temperature of no higher than 25 ° C.

Shelf life:

Shelf life 3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LS-000974

Date of registration:22.04.2011

The owner of the registration certificate:SHREYA LIFE SENENSIZ Pvt.Ltd. SHREYA LIFE SENENSIZ Pvt.Ltd. India

Manufacturer: & nbsp

SHREYA LIFE SCIENCES, Pvt.Ltd. India

Representation: & nbspSHREYA LIFE SENENSIZ Pvt.Ltd. SHREYA LIFE SENENSIZ Pvt.Ltd. India

Information update date: & nbsp16.09.2015

Illustrated instructions

Instructions

Pyracetam (Piracetam)