The undesirable drug reactions listed below were detected in clinical trials and post-detection observations and grouped according to system-organ classes. The frequency gradient is defined as follows: very often (≥1 / 10), often (≥1 / 100 to <1/10), infrequently (≥1 / 1000 to <1/100), rarely (≥1 / 10000 to <1 / 1000), very rarely (<1/10000) and the frequency is unknown (it is impossible to estimate based on the available clinical trial data).
From the side of the blood and lymphatic system:
The frequency is unknown: bleeding.
From the immune system:
The frequency is unknown: anaphylactoid reactions, hypersensitivity.
From the side of the psyche:
Often: nervousness. Infrequently: depression.
The frequency is unknown: agitation, anxiety, confusion, hallucinations.
From the nervous system:
Often: hyperactivity. Infrequently: drowsiness. The frequency is unknown: ataxia, imbalance, exacerbation of epilepsy, headache, insomnia, tremor.
From the side of the organ of hearing and labyrinth:
Frequency unknown: vertigo.
From the side of the vessels:
Rarely: thrombophlebitis, arterial hypotension (only with parenteral administration).
From the digestive system:
The frequency is unknown: abdominal pain (including in the upper parts), nausea, vomiting, diarrhea.
From the skin and subcutaneous tissues:
The frequency is unknown: angioedema, dermatitis, itching, urticaria.
On the part of the reproductive system:
Frequency unknown: increased sexual desire.
Common disorders and disorders at the site of administration:
Infrequently: asthenia.
Rarely: pain at the injection site, fever (only with parenteral administration).
Laboratory and instrumental data:
Often: weight gain.