Intravenous or intramuscular.
Parenteral administration of piracetam is given if oral administration of the drug is not possible (tablets, capsules, oral solution), for example, if swallowing is difficult or when the patient is unconscious, with intravenous administration being preferred.
Intravenous infusion of a daily dose is performed through a catheter at a constant rate for 24 hours a day (for example, coma or at the initial stage of treatment with severe myoclonia). Preliminary preparation is diluted in one of the compatible infusion solutions: dextrose 5%, 10% or 20%, fructose 5%, 10% or 20%, sodium chloride 0.9%, hydroxyethyl starch 6% or 10%, Ringer, mannitol 20%. The total volume of solution intended for administration is determined taking into account the clinical indications and the patient's condition.
Intravenous administration (for example, urgent treatment sickle-cell vaso-occlusive crisis) is performed for at least 2 min, the daily dose is then distributed into several injections at uniform intervals.
Intramuscularly the drug is administered if the introduction through the vein is difficult or the patient is overexcited. However, the amount of the drug that can be administered intramuscularly is limited, especially in children and patients with a reduced body weight. In addition, the administration of the drug intramuscularly can be painful due to the large volume of fluid. The volume of the solution administered intramuscularly can not exceed 5 ml.The frequency of administration of the drug is similar to that of its intravenous or oral administration.
If there is an opportunity, they switch to oral administration of the drug (see instructions for the medical use of the appropriate forms of release of the drug).
The duration of treatment is determined by the doctor depending on the disease and taking into account the dynamics of the symptoms.
Symptomatic treatment of psycho-organic syndrome - 4.8 g / day during the first week, then go to a maintenance dose of 1.2-2.4 g / day.
Treatment of dizziness and related imbalances - 2.4-4.8 g / day.
Treatment of cortical myoclonia - start with a dose of 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until the maximum dose of 24 g / day is reached. Treatment continues throughout the period of the disease. Every 6 months, you should try to reduce the dose or cancel the drug, gradually reducing the dose by 1.2 g / day every 2 days. With little or no therapeutic effect, treatment is discontinued.
Sickle-cell vaso-occlusive crisis (in adults and children). The daily preventive dose is 160 mg / kg body weight divided into 4 equal doses.During the crisis, 300 mg / kg / day intravenously, divided into 4 equal doses.
Treatment of dyslexia in children older than 8 years (in combination with other methods of treatment). The recommended daily dose is 3.2 g divided into 2 equal doses.
Dosing to patients with impaired renal function. Because the piracetam is excreted from the body by the kidneys, care should be taken when treating patients with renal insufficiency and to select a dose in accordance with this dosing regimen:
| Renal insufficiency | CK (ml / min) | Dosing regimen |
| Norm | >80 | the usual dose of 2-4 admission |
| Lightweight | 50-79 | 2/3 of the usual dose in 2-3 doses |
| Average | 30-19 | 1/3 of the usual dose in 2 divided doses |
| Heavy | <30 | 1/6 of the usual dose once |
| The final stage | - | contraindicated |