Inside, during meals or on an empty stomach, squeezed with liquid.
Attention! The last single dose should be taken no later than 17 hours.
In memory disorders, intellectual disorders:
On 2,4-4,8 g / day in several receptions during the first several weeks, then pass to supporting therapy of 2,4 g / day in 2-3 receptions, reception of 1,2 g / day is possible.
Treatment of cortical myoclonia: Treatment begins with a dose of 7.2 g / day, increasing it by 4.8 g / day every 3-4 days to a maximum dose of 24 g / day. The daily dose of piracetam should be divided into 2-4 admission. The dose of other drugs for the treatment of myoclonus does not change. Then, in the future, according to the results of treatment, it is allowed to review the dose of other drugs for the treatment of myoclonus.
After initiation of piracetam treatment, treatment is continued as long as the symptoms of the disease persist. In patients with acute course of the disease, spontaneous improvement can occur over time, therefore every 6 months, attempts should be made to reduce the dose or to abolish the drug.
For this, the dose of piracetam is reduced by 1.2 g every 2 days (every 3-4 days in the case of Lance and Adams syndromes, in order to avoid a sudden relapse of myoclonus). This allows you to know the average effective dose.
Elderly patients with renal insufficiency a dose adjustment should be performed (see "Renal failure" below). With long-term treatment to assess the need for dose adjustment, creatinine clearance should be assessed regularly.
Renal insufficiency
Piracetam is excreted almost exclusively by the kidneys, care should be taken when treating patients with renal insufficiency or requiring renal function control.
The elimination half-life increases in direct proportion to the impairment of kidney function and creatinine clearance; this is also true for the elderly, in whom the excretion of creatinine depends on age.
In this regard, the dose is adjusted in accordance with the table below:
| Kidney function | CK (ml / min) | Dosing regimen |
| Norm | >80 | The standard dose of 2-4 admission |
| Mild renal insufficiency | 50-79 | 2/3 of the standard dose in 2-3 doses |
| Mean renal insufficiency | 30-49 | 1/3 of the standard dose in 2 divided doses |
| Severe renal insufficiency | <30 | 1/6 of the standard dose once |
| Terminal Renal Failure | - | Contraindicated |
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Liver failure
Patients with isolated dysfunction of the liver do not need correction of the dose. Patients with dysfunction of the liver and kidneys are dosed according to the scheme above (see "Renal failure").