Intravenously sprayed or drip, intramuscularly.
Parenteral administration of piracetam is given when oral dosage forms are not possible(tablets, capsules, oral solution), for example, with difficulty swallowing or when the patient is unconscious. Intravenous administration is preferred.
Intravenous infusion of a daily dose is performed through a catheter at a constant rate for 24 hours a day (for example, coma or at the initial stage of treatment with severe myoclonia). Preliminary preparation is diluted in one of the compatible infusion solutions: dextrose 5%, 10% or 20%, fructose 5%, 10% or 20%, sodium chloride 0.9%, dextran [average molecular weight 30,000-40000] (10% in solution of sodium chloride 0.9%), Ringer, mannitol 20%. The total volume of solution intended for administration is determined taking into account the clinical indications and the patient's condition. Bolus intravenous administration (for example, urgent treatment of sickle cell anemia) is performed for at least 2 minutes, the daily dose is then divided into several injections (2-4) at regular intervals so that the dose per administration does not exceed 3 g.
Intramuscularly the drug is administered if the introduction through the vein is difficult or the patient is overexcited. However, the amount of the drug that can be administered intramuscularly is limited, especially in children and patients with reduced body weight.In addition, the administration of the drug intramuscularly can be painful because of the large volume of fluid. The volume of the solution administered intramuscularly can not exceed 5 ml. The frequency of administration of the drug is similar to that of its intravenous or oral administration.
If there is an opportunity, they switch to oral administration of the drug (see instructions for the medical use of the appropriate forms of release of the drug).
The duration of treatment is determined by the doctor depending on the disease and taking into account the dynamics of the symptoms.
Symptomatic treatment of psycho-organic syndrome: 4.8 g / day during the first week, then pass to the maintenance dose - 1.2-2.4 g / day.
Treatment of dizziness and related imbalances: 2.4-4.8 g / day.
Treatment of cortical myoclonia: begin with a dose of 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until a maximum dose of 24 g / day is reached. Treatment continues throughout the period of the disease. Every 6 months, you should try to reduce the dose or cancel the drug, gradually reducing the dose by 1.2 g / day every 2 days. With little or no therapeutic effect, treatment is discontinued.
When the sickle-cell vaso-occlusive crisis is stopped (in adults and children): IV in 300 mg / kg / day, divided into 4 equal doses.
Treatment of dyslexia in children older than 8 years (in conjunction with other methods of treatment) - 3.2 grams, divided into 2 equal doses.
For chronic mild renal insufficiency (creatinine clearance 50-79 ml / min) - 2/3 of the daily dose, divided into 2-3 doses; average (creatinine clearance 30-49 ml / min) - 1/3 dose divided into 2 doses; severe (creatinine clearance 20-30 ml / min) - 1/6 dose once.