Intravenous or intramuscular.
Intravenous infusion of a daily dose is performed through a catheter at a constant rate for 24 hours a day (for example, coma or at the initial stage of treatment with severe myoclonia).Preliminary preparation is diluted in one of the compatible infusion solutions: dextrose 5%, 10% or 20%, fructose 5%, 10% or 20%, sodium chloride 0.9%, dextran (average molecular weight 35000-45000) (10% in solution of sodium chloride 0.9%), Ringer, mannitol 20 %. The total volume of solution intended for administration is determined taking into account the clinical indications and the patient's condition.
Bolus intravenous administration (for example, with the withdrawal of withdrawal syndrome with alcoholism, emergency treatment of sickle cell anemia, etc.) is performed for at least 2 minutes, the daily dose is then divided into several injections (2-4) at regular intervals so , so that the dose for one administration is not exceeded 3 g. Intramuscularly the drug is administered if the introduction through the vein is difficult or the patient is overexcited. However, the amount of the drug that can be administered intramuscularly is limited, especially in children and patients with reduced body weight. In addition, the administration of the drug intramuscularly can be painful because of the large volume of fluid. The volume of the solution administered intramuscularly can not exceed 5 ml. The frequency of administration of the drug is similar to that of its intravenous application.
The duration of treatment is determined by the doctor depending on the disease and taking into account the dynamics of the symptoms.
When treatment of chronic psychoorganic syndrome prescribe the drug in a dose of 2.4-4.8 g / day.
When treatment of the consequences of ischemic stroke piracetam should be prescribed in a dose of 4.8-12 g / day. .
When treatment of coma, as well as difficulties in perception in people with brain trauma the initial dose is 9-12 g / day, supporting - 2 g / day. Treatment should be continued for at least 3 weeks.
When treatment of alcohol withdrawal syndrome the dose of the drug reaches 12 g / day. The maintenance dose is 2.4 g / day.
When treatment of dizziness and related imbalances the dose is 2.4-4.8 g / day.
When treatment of cortical myoclonia treatment starts with a dose of 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until the maximum dose of 24 g / day is reached. Later on they switch to the oral form of piracetam. Treatment with piracetam is continued throughout the period of the disease. Every 6 months, attempts should be made to reduce the dose or discontinue the drug, gradually reducing the dose by 1.2 g / day every 2 days. In the absence of effect or a slight therapeutic effect, treatment is discontinued.
When treatment of sickle cell anemia during the crisis, the dose is up to 300 mg / kg intravenously divided into 4 equal doses. The daily preventive dose is 160 mg / kg body weight divided into 4 equal doses.
When treatment of dyslexia the recommended daily dose for children from 8 years and adolescents - 3.2 g, divided into 2 injections.
Dosing to patients with impaired renal function
Because the piracetam is excreted from the body by the kidneys, care should be taken when treating patients with renal insufficiency and to select a dose in accordance with this dosing regimen:
| Renal insufficiency | Creatinine clearance (ml / min) | Dosage: |
| norm | >80 | usual dose |
| easy | 50-79 | 2/3 of the usual dose for 2-3 injections |
| mean | 30-49 | 1/3 of the usual dose for 2 injections |
| Heavy | 20-29 | 1/6 of the usual dose once |
| final stage | <20 | contraindicated |
Elderly, the dose is corrected in the presence of renal failure and with prolonged therapy requires monitoring of the functional state of the kidneys.
Dosing to patients with impaired liver function
Patients with impaired liver function do not need dose adjustment. Patients with impaired functions and kidneys and liver, dosing is carried out according to the scheme (see the section "Dosing to patients with impaired renal function").