Active substancePirantelePirantele
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  • Dosage form: & nbspSuspension for oral administration.
    Composition:

    Suspension for oral administration contains: pyrantel pamoate 250 mg in 5 ml

    Excipients

    carboxymethylcellulose sodium, sodium methylparaben, sodium propylparaben, sorbic acid, sucrose, citric acid, sorbitol 70%, polysorbate 80, chocolate essence, essence of ice cream, purified water.

    Description:

    Homogeneous suspension of yellow or light yellow color.

    Pharmacotherapeutic group:Anthelminthic agent.
    ATX: & nbsp

    P.02.C.C.01   Pirantele

    Pharmacodynamics:

    Anthelmintic preparation of a wide spectrum of action.It causes blockade of sensitive helminths. Active with respect to Enterobius vermicularis. Ascaris lumbricoides, Ancylostoma doudenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It acts on both sexually mature and immature individuals of both sexes, does not affect the larvae in the stage of migration.

    Pharmacokinetics:

    Suction

    After oral administration pirantele poorly absorbed from the digestive tract. After taking a single dose of 10 mg / kg body weight, the concentration of pyrantel in the plasma is 0.005-0.13 μg / ml for 1-3 hours.

    Distribution

    There is no data on the distribution of pyrantel in tissues and body fluids (theoretically the absorption of the active substance is minimal), as well as the possibility of isolating the active substance with breast milk.

    Metabolism and excretion

    Pyrantel, absorbed into the systemic bloodstream, is partially metabolized in the liver to N-methyl-1,3-propanediamine. 50% of the accepted dose is excreted unchanged with feces, about 7% - with urine in unchanged form or in the form of a metabolite.

    Indications:

    • ascaridosis;
    • ankylostomiasis;
    • necropsy;
    • enterobiosis.

    Contraindications:

    • hypersensitivity to pyrantel;
    • myasthenia gravis (treatment period).

    Carefully:

    With caution appoint with liver failure.

    Pregnancy and lactation:

    The use of the drug in pregnancy and lactation (breastfeeding) is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or child.

    Dosing and Administration:

    Established individually, depending on the age and body weight of the patient.

    Age - Dose of the drug

    Children from 6 months to 2 years - 125 mg (1/2 tab.)

    Children from 2 to 6 years - 250 mg (1tab.)

    Children from 6 to 12 years - 500 mg (2 tab.)

    Children over 12 years and adults weighing less than 75 kg - 750 mg (3 tab.)

    Adults with a body weight of more than 75 kg - 1000 mg (4 tab.)

    When ascaridosis and enterobiasis the drug is administered once in a dose at the rate of 10 mg / kg body weight. In some cases, the use of the drug in a minimum dose of 5 mg / kg is acceptable.

    When ankylostomidosis prescribe in a dose of 10 mg / kg / day for 3 days.

    In severe forms of non-katorosis (massive invasions Necator americanus) prescribe in a dose at the rate of 20 mg / kg / day for 2 days.

    The drug is taken during or after meals, the tablet should be thoroughly chewed.

    Side effects:

    From the gastrointestinal tract and liver: nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of hepatic transaminases.

    From the side of the central nervous system: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing impairment, hallucinations, confusion, paresthesia.

    Other: skin rash, fever.

    Overdose:

    At present, no cases of overdose have been reported. If necessary, conduct symptomatic therapy.

    Interaction:

    When combined with piperazine Pirantele acts antagonistically (this combination is not recommended). Increases the concentration of theophylline in plasma.

    Special instructions:

    When enterobiosis should be a simultaneous treatment of all living together.

    After completion of treatment, it is necessary to conduct a control study of feces for the presence of eggs of parasites.

    Form release / dosage:

    Suspension for oral administration 250 mg / 5 ml.

    Packaging:

    For 10 ml of the suspension in a glass bottle of amber color, sealed with a screw cap with a PVC liner and a measuring cap, together with the medical instruction, they are placed in a cardboard box.

    Storage conditions:

    List B.

    The drug should be stored in a dry, dark place at a temperature below 25 ° C.

    Shelf life:

    Tablets 4 years.

    Suspension is 3 years.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N014486 / 01-2002
    Date of registration:25.11.2008
    The owner of the registration certificate:Ipka Laboratories Ltd.Ipka Laboratories Ltd. India
    Manufacturer: & nbsp
    Representation: & nbspIPKA LABORATORIES LTD. IPKA LABORATORIES LTD. India
    Information update date: & nbsp10.09.2015
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