Pirentel - instructions for use, doses, side effects, contraindications

Active substance: pyrantel 250 mg (in the form of pyrantel embonate 720 mg) Excipients: ethylcellulose, povidone, magnesium stearate, talc, orange flavor, potato starch.

Description:

Tablets of yellow color with a gray-green shade, round, flat, with a risk and a facet. The tablets have a faint orange smell.

Tablets darken under the influence of light, changing the color to yellow-brown. Allowed a slight marbling.

Pharmacotherapeutic group:Anthelminthic remedy

ATX: & nbsp

P.02.C.C.01 Pirantele

Pharmacodynamics:

Pyrantel is an antihelminthic agent that acts on nematodes. It causes neuromuscular blockade in sensitive helminths, which facilitates their removal from the digestive tract without stimulation and stimulation of migration of affected worms.

The drug acts on parasites in the early phase of development and on their mature forms, does not affect the larvae during their migration into tissues.

Pirantel is highly effective against infestations caused by pinworms (Enterobius vermicularis), hookworms (Ancylostoma doudenale, Necator americanus), against the causative agents of trichocephalosis (Trichostrongylus orientalis and Trichostrongylus colubriformis) and ascariasis (Ascaris lumbricoides).

Pharmacokinetics:

Pirantel is very poorly absorbed from the digestive tract.

Concentration of the drug in the blood plasma, after oral administration of a single dose of 10 mg / kg body weight, is 0.005-0.13 μg / ml for 1 to 3 hours.

There are no data on the penetration of the drug through the placenta and into the milk of the lactating woman, and also regarding the distribution of the drug in the tissues and body fluids (theoretically, the resorption of the drug is minimal). The minimum amount of the drug resorbed from the digestive tract is partially metabolized in the liver to Nmethyl-1,3-propanediamine.

About 93% of the oral dose of the drug is excreted unchanged in the intestine and not more than 7% by the kidneys in unchanged form or in the form of a metabolite of N-methyl-1,3-propanediamine.

Indications:

Ascaridosis
Enterobiosis
Ankylostomiasis
Nekatoroz
Trichocephalosis

Contraindications:

Hypersensitivity to the drug;
myasthenia gravis (treatment period);
Children under 3 years old (for this dosage form).

Carefully:

Pregnancy, lactation, liver failure.

Pregnancy and lactation:

There are no controlled studies of the use of Pirantel in pregnant women, so the drug should be used only if the potential benefit to the mother exceeds the possible risk to the fetus.

Application during lactation

There are no data on the safety of the drug in lactating women. During the period of breastfeeding the child the drug should be used only in case of unconditional necessity.

Dosing and Administration:

Inside.

The drug is used during or after a meal, thoroughly chewing the tablet, drinking 1 glass of water.

If no other treatment regimen is prescribed, depending on the age and weight of the patient, the following dosages are recommended:

Patient's age	Tablets 250 mg	mg
3-6 years old	1	250
6- 12 years	2	500
older than 12 years and adults weighing up to 75 kg	3	750
adults weighing more than 75 kg	4	1000

To avoid self-invasion, it is possible to repeat the course 3 weeks after the first dose.

With isolated ascariasis, the use of pyrantel is recommended at 5 mg / kg, once.

With ascariasis and enterobiasis, as well as mixed infestations with these parasites, the dose intended for the entire course (at the rate of 10 mg / kg) is applied once.

With ankylostomiasis, a combination of non-katorosis with ascariasis or other combined helminthic lesions pirantele apply for 3 days to 10 mg / kg per day.

In massive invasions of Necator americanus, a dose of 20 mg / kg of body weight is recommended for 2 days.

Side effects:

Side effects are rare, they are short-lived and disappear after discontinuation of treatment.

Most side effects are manifested by the digestive tract: nausea, vomiting, lack of appetite, diarrhea, pain and stomach cramps

Rarely - headache, dizziness, drowsiness or insomnia, weakness, rash, fever, a transient increase in serum ACT.

In isolated cases, hearing disorders of hallucinations with confusion and paresthesia were observed (the relationship of these symptoms with the drug is not proven).

Overdose:

Cases of overdose are not described.

In case of an overdose, symptomatic treatment should be undertaken.

Interaction:

Pyrantel should not be used together with piperazine. These funds act antagonistically.

Pirantel increases the concentration of theophylline in plasma.

Special instructions:

After taking pyrantel, laxatives are not prescribed. In the treatment of enterobiasis, all co-residents must be treated simultaneously. Careful hygiene (cleaning of living quarters and cleaning clothes for the destruction of helminth eggs) is a preventive measure of reinfection. 14 days after drug treatment pirantele should conduct control parasitologic studies.

Effect on the ability to drive transp. cf. and fur:

Given the possible side effects of the nervous system during the use of the drug should be careful when dealing with potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Tablets 250 mg.

Packaging:

3 tablets in a contour non-cellular package (strip) made of aluminum foil, laminated with polyethylene.

On 1 strip together with the Instruction for use put in a cardboard box.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

5 years.

Do not use the drug after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:П N014859 / 01

Date of registration:25.08.2009

The owner of the registration certificate:Pharmaceutical factory "POLFARMA" JSCPharmaceutical factory "POLFARMA" JSC Poland

Manufacturer: & nbsp

POLPHARMA PHARMACEUTICAL WORKS, S.A. Poland

Representation: & nbspAKRIKHIN OJSC AKRIKHIN OJSC Russia

Information update date: & nbsp10.08.2015

Illustrated instructions

Instructions

Pirantele (Pyrantel)