Pirentel - instructions for use, doses, side effects, contraindications

Auxiliary substances: sorbic acid, sucrose, xanthan gum, methylparahydroxybenzoate, propyl parahydroxybenzoate, sorbitol 70% solution, polysorbate 80, chocolate flavor S 2761 (composition: propylene glycol, water, caramel dye, natural, natural and artificial aromatic substances), ice cream flavor "(composition: propylene glycol, water, caramel dye, natural,identical to natural and artificial aromatic substances), purified water.

Description:

Homogeneous suspension of yellow color.

Pharmacotherapeutic group:Anthelminthic remedy

ATX: & nbsp

P.02.C.C.01 Pirantele

Pharmacodynamics:

Anthelmintic preparation of a wide spectrum of action. It causes a neuromuscular blockade of sensitive helminths. It is active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It acts on both sexually mature and immature individuals of both sexes, does not affect the larvae in the stage of migration.

Pharmacokinetics:

Suction

After oral administration pirantele poorly absorbed from the gastrointestinal tract (GIT). After taking a single dose of 10 mg / kg body weight, the concentration of pyrantel in the plasma is 0.005-0.13 μg / ml for 1-3 hours.

Distribution

There is no data on the distribution of pyrantel in tissues and body fluids (theoretically the absorption of the active substance is minimal), as well as the possibility of isolating the active substance with breast milk.

Metabolism and excretion

Pyrantel absorbed into the systemic bloodstream is partially metabolized in the liver to N-methyl-1,3-propanediamine.93% of the accepted dose is excreted unchanged with feces, about 7% - with urine in unchanged form or in the form of metabolite.

Indications:

ascaridosis;
ankylostomiasis;
necropsy;
enterobiosis;
trichocephalus.

Contraindications:

hypersensitivity to pyrantel;
myasthenia gravis (treatment period).

Carefully:

With caution appoint for liver failure and children up to 6 months.

Pregnancy and lactation:

The use of the drug in pregnancy and lactation (breastfeeding) is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or child.

Dosing and Administration:

With ascariasis and enterobiasis, with mixed invasions these helminths - inside, once, after breakfast at the rate of 10 mg / kg. Adults and children older than 12 years - 750 mg, with a body weight of more than 75 kg - 1 g] Children from 6 months to 2 years - 125 mg, 2-6 years - 250 mg, 6-12 years - 500 mg. To avoid self-invasion, it is possible to repeat the course after 3 weeks. after the first reception.

In ankylostomiasis, a combination of non-katorosis with ascariasis or other combined helminthic lesions, 10 mg / kg / day are prescribed for 3 days or 20 mg / kg / day for 2 days.

With isolated ascariasis - 5 mg / kg once.

Side effects:

On the part of the gastrointestinal tract and liver: nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of hepatic transaminases.

From the central nervous system (CNS): rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases, hearing impairment, hallucinations, confusion, paresthesia.

Other: skin rash, fever.

Overdose:

At present, no cases of overdose have been reported. If necessary, conduct symptomatic therapy.

Interaction:

When combined with piperazine adipinate Pirantele acts antagonistically (this combination is not recommended).

Increases the concentration of theophylline in plasma.

Special instructions:

When enterobiosis should be a simultaneous treatment of all living together. After completion of treatment, it is necessary to conduct a control study of feces for the presence of eggs of parasites.

Effect on the ability to drive transp. cf. and fur:

Data on the impact on driving and maintenance of mechanical equipment are not available.

Form release / dosage:

Suspension for oral administration 250 mg / 5 ml.

Packaging:

For 15 ml of the drug in a bottle of dark glass with a screw cap and a measuring cap. Each bottle is placed in a cardboard box with instructions for use.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.

Do not use the drug after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:П N013548 / 02-2001

Date of registration:01.08.2008

The owner of the registration certificate:Oxford Laboratories Pvt. Ltd.Oxford Laboratories Pvt. Ltd. India

Manufacturer: & nbsp

OXFORD Laboratories, Pvt. Ltd. India

Representation: & nbspOXFORD LABORATORY Pvt. Ltd. OXFORD LABORATORY Pvt. Ltd. India

Information update date: & nbsp10.08.2015

Illustrated instructions

Instructions

Pirantele (Pyrantel)