Active substancePirantelePirantele
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  • Dosage form: & nbsp

    Pills

    Composition:

    Each tablet contains:

    Active substance: pyrantel pamoate equivalent to the base pyrantel 250 mg; auxiliary substances: corn starch, gelatin, talc purified, magnesium stearate, sodium carboxymethyl starch.

    Description:

    Oval biconvex tablets are yellow in color with a risk on one side.

    Pharmacotherapeutic group:Anthelminthic remedy
    ATX: & nbsp

    P.02.C.C.01   Pirantele

    Pharmacodynamics:

    Pirantela pamoat anthelmintic preparation of a wide spectrum of action. The mechanism of action is associated with the blocking of neuromuscular conduction in helminths.It is active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma doudenale, Necator Americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It acts on both sexually mature and immature individuals of both sexes, does not affect the larvae in the stage of migration.

    Pharmacokinetics:

    After oral administration pirantele poorly absorbed from the digestive tract. After taking a single dose of 10 mg / kg body weight, the concentration of pyrantel in the plasma is 0.005-0.13 μg / ml for 1-3 hours. Pirantele, absorbed into the systemic circulation, is partially metabolized in the liver before Nmethyl-1,3-propanediamine. 50% of the accepted dose is excreted unchanged with feces, about 7% - with urine in unchanged form or in the form of a metabolite.

    Indications:

    The main indications for use are ascaridosis, ankylostomidosis, non-carotidosis and enterobiosis.

    Contraindications:

    Myasthenia gravis (treatment period);

    Children up to 3 years of age (solid dosage form);

    Hypersensitivity to pyrantel and other components of the drug.

    Carefully:

    Liver failure.

    Pregnancy and lactation:

    When pregnancy is used only if the intended benefit for the mother exceeds the risk to the fetus.

    When used during lactation it is recommended to stop breastfeeding.

    Dosing and Administration:

    The drug is prescribed inside during or after a meal and the dosage is set individually depending on the age and body weight of the patient.

    Ascaridosis and enterobiasis, as well as mixed invasions - once in a dose of 10 mg / kg body weight.

    Age - Dose of the drug

    Children 3 years - 6 years - 250 mg (1 tab.)

    Children 6 years-12 years - 500 mg (2 tab.)

    Children over 12 years and adults with a body weight of <75 kg - 750 mg (3 tablets).

    Adults with a body weight> 75 kg - 1000 mg (4 tab.)

    The tablet should be thoroughly chewed.

    Ankylostomidosis: the drug is prescribed at the rate of 10 mg / kg of body weight per day for 3 days.

    Necatosis: in severe forms, the drug is prescribed at a dose of 20 mg / kg of body weight per day for 2 days.

    Side effects:

    On the part of the gastrointestinal tract and liver: a decrease in appetite, nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of hepatic transaminases.

    From the side CNS rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing impairment, hallucinations, confusion, paresthesia.

    Other: skin rash, hives, fever.

    Overdose:

    Treatment: gastric lavage. There is no specific antidote.

    Interaction:

    Do not assign a simultaneous piperazine (weakening action).

    With simultaneous application pirantele increases the concentration of theophylline in plasma.

    Special instructions:

    After taking pyrantel, a laxative is not prescribed.

    When enterobiosis should be a simultaneous treatment of all living together. After completion of treatment, it is necessary to conduct a control study of feces for the presence of eggs of parasites. Care must be taken to ensure hygiene (cleaning of living quarters and cleaning of clothes for the destruction of helminth eggs serves as prevention of reinfection
    Form release / dosage:

    Tablets 250 mg.

    Packaging:

    For 3 tablets in a strip of aluminum foil or in a blister of PVC / aluminum foil.

    1 strip or 1 blister is placed in a cardboard box together with instructions for use.

    Storage conditions:

    In a dry, protected from light place at a temperature of no higher than 25 * C. Keep out of the reach of children.

    Shelf life:

    3 years. Do not use the drug with expired shelf life.

    Terms of leave from pharmacies:On prescription
    Registration number:П N013548 / 01
    Date of registration:31.07.2008
    The owner of the registration certificate:Oxford Laboratories Pvt. Ltd.Oxford Laboratories Pvt. Ltd. India
    Manufacturer: & nbsp
    Representation: & nbspOXFORD LABORATORY Pvt. Ltd. OXFORD LABORATORY Pvt. Ltd. India
    Information update date: & nbsp10.08.2015
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