Active substancePirantelePirantele
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    OZONE, LLC     Russia
  • Pirantele
    suspension inwards 
  • Pirantele
    pills inwards 
  • Pirantele
    suspension inwards 
  • Pirantele
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  • Pirantele
    suspension inwards 
    ATOLL, LLC     Russia
  • Pirantele
    pills inwards 
  • Pirantele
    suspension inwards 
  • Dosage form: & nbsp

    Suspension for oral administration.

    Composition:

    Composition per 5 ml of suspension:

    Active substance: pyrantel pamoate - 721.0 mg, in terms of pyrantel - 250.0 mg. Excipients: sodium benzoate 15.0 mg, carmellose sodium 15.0 mg, sorbitol noncrystallizing 70% 3605.0 mg, glycerol 303.5 mg, magnesium aluminosilicate 16.5 mg, polysorbate 80 80, 0 mg, povidone-K25 - 100.0 mg, citric acid monohydrate 1.5 mg, simethicone (emulsion) 2.5 mg, fruit flavor 2.5 mg, water up to 5 ml.

    Description:

    Suspension of light yellow color with a characteristic odor. It is allowed to separate the liquid layer and the sediment, after stirring, a uniform suspension is formed.

    Pharmacotherapeutic group:Anthelminthic remedy
    ATX: & nbsp

    P.02.C.C.01   Pirantele

    Pharmacodynamics:

    Anthelminthic drug, causes neuromuscular blockade of sensitive helminths and ensures their expulsion without stimulation and stimulation of migration of affected worms. It acts on both sexually mature and immature individuals of both sexes. It is active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus.

    Pharmacokinetics:

    Virtually not absorbed from the gastrointestinal tract. After taking a single dose of 10 mg / kg, the concentration in the blood plasma is 0.005-0.13 μg/ml and is achieved within 1-3 hours. It is partially metabolized in the liver to N-methyl-1,3-propanediamine. Excretion of the intestine - about 93% unchanged, 7% - kidneys in unchanged form or in the form of a metabolite.

    Indications:

    Ascaridosis, enterobiasis, ankylostomiasis (including non-carotidosis).

    Contraindications:

    Hypersensitivity to pyrantel and other components of the drug; myasthenia gravis; liver failure; children up to 6 months.

    Carefully:

    With caution: children age from 6 months to 6 years and body weight less than 10 kg.

    Pregnancy and lactation:

    When pregnancy is used only if the intended benefit for the mother exceeds the potential risk to the fetus.If it is necessary to use the drug during lactation, breastfeeding should be stopped.

    Dosing and Administration:

    For oral administration.

    Suspension before use is shaken.

    1 ml of the suspension contains 50 mg of pyrantel.

    Pyrantel can be taken at any time of the day, not necessarily on an empty stomach. Before and after taking the drug laxatives do not apply.

    Ascaridosis, enterobiosis:

    When enterobiosis, as well as mixed invasions (enterobiosis and ascariasis), the dose intended for the entire course (based on 10 mg / kg of body weight) is applied once. Children from 6 months to 2 years: 2.5 ml of suspension (125 mg);

    Children from 2 years old with a body weight of more than 12 kg to 6 years: 5 ml of suspension (250 mg);

    Children from 6 to 12 years; 10 ml of suspension (500 mg);

    Children over 12 years of age and adults weighing less than 75 kg: 15 ml of suspension (750 mg); Adults with a body weight of more than 75 kg: 20 ml of suspension (1000 mg).

    To prevent re-infection, it is recommended to repeat the drug after 3 weeks.

    With isolated ascariasis - 5 mg / kg once.

    Ankylostomidosis:

    In endemic areas, in case of infection with Necator americanus or in case of severe infection with Ancylostoma duodenale, the dosage is 20 mg / kg / day (for one or two doses) for two to three days.

    In case of infection of Ancylostoma duodenale outside endemia zones (it proceeds more easily), apply at a dose of 10 mg / kg at a time.

    Side effects:

    On the part of the gastrointestinal tract: nausea, vomiting, abdominal pain, diarrhea, loss of appetite, increased activity of "liver" transaminases.

    Allergic reactions: itching, urticaria, skin rash.

    From the nervous system: headache, dizziness, weakness, drowsiness, insomnia, hallucinations, confusion, paresthesia.

    From the side of the hearing organ and labyrinthine disorders: hearing impairment.

    Other: hyperthermia.

    Overdose:

    Symptoms: increased dose-related side effects.

    Treatment: symptomatic therapy.

    Interaction:

    It is not recommended simultaneous use of levamisole, piperazine. Increases the concentration of theophylline in plasma.

    Special instructions:

    Special preparation and diet with the drug Pirantele not required. In the case of existing liver disease, the doctor must be warned. It should be remembered that before applying the drug Pirantele, like any other anthelmintic preparation, you should carefully clean the room, wash children's toys, before going to bed and after a shower and change your underwear.Bed linen is advisable during the days of treatment and a few days after taking the drug iron it with a hot iron. To avoid re-infection, you must strictly follow the rules of hygiene: wash your hands, cut and clean your nails, do not allow combing the perineum, change bed and underwear daily. Careful cleaning of living quarters and cleaning clothes for the destruction of helminth eggs serves as a preventive measure of reinfection. At the same time, treatment of all living together is recommended. Infection often may not show any symptoms. After completion of the treatment, it is necessary to conduct a control study of feces for the presence of helminth eggs.

    Effect on the ability to drive transp. cf. and fur:

    During the period of treatment, one should refrain from driving vehicles and practicing other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:

    Suspension for oral administration 250 mg / 5 ml.

    Packaging:

    By 5 ml, 10 ml, 15 ml or 25 ml of the suspension into vials of glass-colored glass of orange glass or polymeric bottles, capped with a polymer lid.

    A label is attached to the bottle on the basis of a self-adhesive film.

    Each bottle, along with instructions for use, as well as a measuring cup or measuring spoon, is placed in a cardboard package (bundle).

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years. Do not use the drug after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-002914
    Date of registration:16.03.2015
    The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp10.08.2015
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