Pyridoxine - instructions for use, dose, side effects, contraindications

Vitamin B6, is involved in the metabolism; is necessary for the normal functioning of the central and peripheral nervous system. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate and is part of the enzymes that carry out decarboxylation and reamination of amino acids. Participates in the exchange of tryptophan, methionine, cysteine, glutamic and other amino acids. It plays an important role in the exchange of histamine. Promotes the normalization of lipid metabolism. Isolated pyridoxine deficiency is very rare, mainly in children who are on special artificial nutrition (manifested by diarrhea, seizures, anemia, peripheral neuropathy may develop).

Indications:

Hypo-and avitaminosis B6 (treatment and prevention).

In complex therapy: diseases of the nervous system (neuralgia, Meniere's syndrome);
In dermatology: seborrheic and non-seborrheic dermatitis, shingles, neurodermatitis, psoriasis, exudative diathesis and other diseases;
Toxicosis of pregnant women: anemia (hypochromic, microcytic, sideroblastic);
Acute and chronic hepatitis.

The drug increases diuresis and intensifies the action of diuretics.Pyridoxine hydrochloride prevents or reduces toxic manifestations, including liver damage, when using isoniazid and other anti-tuberculosis drugs.

Contraindications:

Hypersensitivity to the components of the drug.

Carefully:Peptic ulcer of the stomach and duodenum (due to the possible increase in the acidity of the gastric juice), coronary heart disease, severe liver damage.

Dosing and Administration:

The daily need for pyridoxine for adult men and women is 2 mg, for children and adolescents, depending on the age of 0.4 - 2 mg. For prophylaxisB6-hypovitaminosis, adults are prescribed 2-5 mg per day, children - 2 mg per day. Inside the drug is used after eating. Therapeutic doses for oral administration are 50-100 mg 1-2 times a day for adults; for children, the dose is reduced according to age. The course of treatment is 1-2 months. When using isoniazid, ftivazid or other derivatives of hydrazide isonicotinic acid, it is advisable to prescribe pyridoxine 5-10 mg per day prophylactically (to prevent violations of the central nervous system).For the treatment of sideroblastic anemia, 100 mg daily is administered intravenously. It is advisable to simultaneously take folic acid, cyanocobalamin, riboflavin.

Side effects:

Allergic reactions (skin rashes, etc.), hypersecretion of hydrochloric acid.

Interaction:

Pyridoxine hydrochloride is not prescribed together with L-dofa (levodopa), since the action of the latter is weakened. Strengthens the action of diuretics. Isonicotin hydrazide, penicillamine, cycloserine and estrogen-containing oral contraceptives weaken the effect of pyridoxine.

Form release / dosage:Tablets 10 mg.

Packaging:

For 50 tablets in cans of light-protective glass or in cans of polymeric, or polymeric bottles.
For 10 tablets in a contour mesh package or a cell-free package.
Each jar or bottle, or 1, 2, 3, 4 or 5 contour squares, together with the instruction for use, is placed in a pack of cardboard.
It is allowed to use polymer cans or polymer bottles without packs, contour non-cellular packages with an equal number of instructions for use should be placed in a group package.

Storage conditions:

In a dry place, protected from light, out of reach of children.

Shelf life:

3 years.Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N000083 / 01

Date of registration:08.08.2011

The owner of the registration certificate:VEROPHARM SA VEROPHARM SA Russia

Manufacturer: & nbsp

VEROPHARM SA Russia

Information update date: & nbsp23.09.2015

Illustrated instructions

Instructions

Pyridoxine (Pyridoxine)