Pyridoxine bufus - instructions for use, dose, side effects, contraindications

Vitamin B6 is involved in the metabolism; is necessary for the normal functioning of the central and peripheral nervous system. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate and is part of the enzymes that carry out decarboxylation and reamination of amino acids.

Participates in the exchange of tryptophan, methionine, cysteine, glutamic and other amino acids. It plays an important role in the exchange of histamine. Promotes the normalization of lipid metabolism.

Isolated pyridoxine deficiency is very rare, mainly in children on a special artificial diet. It is manifested by diarrhea, convulsions, anemia, peripheral neuropathy can develop.

The daily need for pyridoxine for adults - 2 - 2.5 mg; for children from 6 months to 1 year - 0.5 mg; 1-1,5 years - 0,9 mg; 1,5-2 years - 1 mg; 3-4 years - 1.3 mg; 5-6 years - 1 mg; 7-10 years - 1.7 mg; 11-13 years - 2 mg; for young men 14-17 years - 2.2 mg; for girls aged 14-17 - 1.9 mg. For women - 2 mg and in addition at pregnancy 0,3 mg, at feeding by a breast - 0,5 mg.

Pharmacokinetics:

Metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxalphosphate and pyridoxamino phosphate). With plasma proteins binds pyridoxalphosphate by 90%.Well absorbed throughout the small intestine, more absorbed in the jejunum, penetrates all tissues; distribution is predominantly in the liver, less in the muscles and central nervous system. Penetrates through the placenta and into the mother's milk. T1 - 15-20 days. It is excreted by the kidneys (with intravenous injection - with bile 2%), as well as with hemodialysis.

Indications:

Hypovitaminosis and vitamin B6.

In complex therapy

in neurology: parkinsonism, paralysis of central or peripheral origin, Little's disease, Meniere's disease and syndrome, sea and air sickness, radiculitis, neuralgia, neuritis.
in dermatology: dermatitis (including seborrhea), shingles, neurodermatitis, psoriasis, exudative diathesis.
toxicosis of pregnant women, anemia (hypochromic, microcytic, sideroblastic).
acute and chronic hepatitis, alcoholism.
to enhance the action of diuretics.
prevention and treatment of neurotoxicity of isoniazid and other anti-tuberculosis drugs.

Congenital pyridoxine-dependent convulsive syndrome of newborns.

Contraindications:

Hypersensitivity.

Carefully:

Caution should be applied pyridoxine in patients with peptic ulcer of the stomach and duodenum (in connection with the possible increase in the acidity of gastric juice), coronary heart disease.

Dosing and Administration:

Pyridoxine is prescribed intravenously, intramuscularly or subcutaneously (if oral administration is not possible, for example, with vomiting and with intussusception of intestinal absorption).

Adult treatment doses are 50-100 mg (1-2 ml of 5% solution) in 1-2 divided doses per day. The course of treatment is 1 month. Children 20 mg (0.5 ml 5% solution) per day, treatment course 2 weeks.

In parkinsonism, 100 mg / day (2 ml of 5%) solution per day intramuscularly. Course - 20-25 injections. After 2-3 months, the course of treatment is repeated. To treat anemia appoint 100 mg intramuscularly 2 times a week. It is advisable to simultaneously take folic acid, cyanocobalamin, riboflavin.

To treat pyridoxine-dependent convulsive syndrome, 100 mg of pyridoxine is administered intramuscularly or intravenously to the newborn.

In the treatment of tuberculosis with isoniazid and ftivazidom 1 g of injected drug should be prescribed 100 mg of pyridoxine (to prevent violations of the functions of the central nervous system).

Side effects:

Allergic reactions, hypersecretion of hydrochloric acid,the appearance of a feeling of numbness and squeezing in the limbs - a symptom of "stocking" and "gloves", a decrease in lactation (sometimes it is used as a curative effect); rarely - convulsions (occur only with rapid administration).

Interaction:

Isoniazid, penicillamine, cycloserine, oral contraceptives containing estrogens, weaken the effect of pyridoxine.

Pharmaceutically incompatible with vitamins thiamine (B1) and cyanocobalamin (AT 12).

Pyridoxine is not prescribed together with levodopa, since the effect of the latter is weakened.

Strengthens the action of diuretics.

Can be used with cardiac glycosides, glutamic acid and potassium and magnesium asparaginate.

Simultaneous use of pyridoxine with cycloserine, ethionamide, hydralazine, azathioprine, chlorambucil, corticotropin, cyclophosphamide, cyclosporine, mercaptopurine, penicillamine - can cause anemia and neuropathy.

Special instructions:

With severe liver damage pyridoxine in large doses can cause a deterioration in its function.

When determining urobilinogen using Ehrlich's reagent, it can distort the results.

Form release / dosage:

Solution for injection 50 mg / ml.

Packaging:

1 ml, 2 ml into polymer ampoules from high pressure polyethylene or from low pressure polyethylene, or from polyethylene for medical purposes, or from polyethylene or polypropylene for infusion solutions and injections. For polymer ampoules, labels from label paper, writing or label text are applied directly to the ampoule by a polymer method of drop-jet printing.

For 10, 100 ampoules of polymer with instructions for use are placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of 12 to 15 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-003163/09

Date of registration:24.04.2009

The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia

Manufacturer: & nbsp

UPDATE, PFC CJSC Russia

Information update date: & nbsp18.10.2015

Illustrated instructions

Instructions

Pyridoxine bufus (Pyridoxine bufus)