Pyridoxine - instructions for use, dose, side effects, contraindications

Vitamin B6, is involved in the metabolism; is necessary for the normal functioning of the central and peripheral nervous system. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate and is part of the enzymes that carry out decarboxylation and reamination of amino acids. Participates in the exchange of tryptophan, methionine, cysteine, glutamic and other amino acids. It plays an important role in the exchange of histamine. Promotes the normalization of lipid metabolism. In parkinsonism, the therapeutic effect is manifested in a decrease in tremor (in contrast to L-Dopa, which primarily affects muscle rigidity).

Pharmacokinetics:

Metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxalphosphate and pyridoxamino phosphate). With plasma proteins binds pyridoxalphosphate by 90%. They are well absorbed and penetrate into all tissues; distribution is predominantly in the liver, less in the muscles and in the central nervous system. Penetrate through the placenta and into the mother's milk. T ½ - 15-20 days. It is excreted by the kidneys (with intravenous administration with bile-2%), as well as with hemodialysis.

Indications:

Treatment of clinical insufficiency of vitamin B6.

Contraindications:

Hypersensitivity to the components of the drug.

Carefully:

Stomach ulcer and duodenal ulcer, ischemic heart disease.

Dosing and Administration:

Parenterally (subcutaneously, intramuscularly, intravenously) if ingestion is not possible (with vomiting) and with impaired absorption in the intestine.

Adults - 0,05-0,1 g each/day in 1-2 reception.

Side effects:

Allergic reactions, hypersecretion of hydrochloric acid, numbness, the appearance of a feeling of compression in the extremities - a symptom of "stocking" and "gloves," a decrease in lactation (sometimes it is used as a therapeutic effect, rarely - convulsions (occur only with rapid intravenous administration).

Interaction:

Strengthens the action of diuretics, weakens the activity of levodopa. Anticonvulsants, corticosteroids, isoniazid, penicillamine, cycloserine, hydralazine, oral contraceptives containing estrogens weaken the effect of pyridoxine.

Pharmaceutically incompatible with vitamins B1 and B12, in powder with ascorbic and nicotinic acids.

Well combined with cardiac glycosides (synthesis of contractile proteins in the myocardium), with glutamic acid and asparcam (increases resistance to oxygen deficiency).

Special instructions:

With severe liver damage pyridoxine in large doses can cause a deterioration in its function. When determining urobilinogen using Ehrlich's reagent, it can distort the results.

Form release / dosage:Injection.

Packaging:

1 ml in neutral glass ampoules. 10 ampoules per box of cardboard. In each box, the scriber is ampouled.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children

Shelf life:

3 years.

Do not use after the date shown on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N 015466/01

Date of registration:04.12.2008

The owner of the registration certificate:StatusPharm, LLC StatusPharm, LLC Russia

Manufacturer: & nbsp

YEREVAN CHEMICAL - PHARMACEUTICAL FIRM, OJSC Armenia

Information update date: & nbsp14.10.2015

Illustrated instructions

Instructions

Pyridoxine (Pyridoxine)