Pyridoxine - instructions for use, dose, side effects, contraindications

Vitamin B6. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate and is part of enzymes that carry out decarboxylation, transamination and racemization of amino acids, as well as enzymatic conversion of sulfur-containing and hydroxylated amino acids.

Participates in the exchange of tryptophan (participation in the reaction of biosynthesis of serotonin).

Isolated pyridoxine deficiency is very rare, mainly in children who are on special artificial nutrition (manifested by diarrhea, seizures, anemia, peripheral neuropathy may develop).

Pharmacokinetics:

Metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxalphosphate and pyridoxamino phosphate). With plasma proteins binds pyridoxalphosphate by 90%. Penetrates into all tissues, distribution is predominantly in the liver, less in the muscles and central nervous system. Penetrates through the placenta, is secreted with breast milk. The half-life is 15-20 days. It is excreted by the kidneys (with intravenous injection with bile - 2%), as well as during hemodialysis.

Indications:

Hypo-and avitaminosis B6.

As part of complex therapy:

in neurology: Parkinsonism, paralysis of central or peripheral origin, Little's disease, Meniere's disease and syndrome, sea and air disease, radiculitis, neuralgia, neuritis.
in dermatology: dermatitis (including atopic and seborrheic), herpetic infections, shingles, neurodermatitis, psoriasis, exudative diathesis.
anemia (hypochromic, microcytic, sideroblastic).
acute and chronic hepatitis, alcoholism.
to increase diuresis and increase the action of diuretics.
prevention and treatment of neurotoxicity of isoniazid and other derivatives of isonicotinic acid hydrazide.

Congenital pyridoxine-dependent convulsive syndrome of newborns.

Contraindications:

Hypersensitivity to the drug.

Carefully:

It should be applied pyridoxine in patients with peptic ulcer of the stomach and duodenum (in connection with the possible increase in the acidity of gastric juice), coronary heart disease.

Pregnancy and lactation:

It is possible to use pyridoxine during pregnancy and lactation (breastfeeding) according to the indications.

Dosing and Administration:

Pyridoxine is administered intravenously, intramuscularly or subcutaneously (if ingestion is not possible, for example, with vomiting and with intussusception of intestinal absorption).

Adults with hypo- and avitaminosis B6 therapeutic doses of 50-100 mg (1-2 ml of 5% solution) in 1-2 divided doses per day. The course of treatment for adults is 1 month.

Children - 20 mg (0.5 ml of 5% solution) per day, treatment course - 2 weeks. In parkinsonism, 100 mg / day (2 ml of 5%) solution per day intramuscularly. The course of treatment - 20-25 injections. After 2-3 months, the treatment course is repeated either starting with a dose of 50-100 mg / day, daily increasing the dose by 50 mg, bringing it to 300-400 mg / day, as a single injection for 12-15 days.

For the treatment of anemia, 100 mg intramuscularly administered twice a week. It is advisable to simultaneously take folic acid, cyanocobalamin, riboflavin.

For the treatment of pyridoxine-dependent convulsive syndrome, adults - intravenously or intramuscularly 30-600 mg; Children - 10-100 mg daily.

At depressions of an involutional age - intramuscularly, on 200 mg / sut.

In the treatment of tuberculosis GINK (hydrazide isonicotinic acid) and its derivatives per 1 g of injected GICA, 100 mg of pyridoxine (to prevent violations of the central nervous system) should be prescribed.

Side effects:

Allergic reactions, hypersecretion of hydrochloric acid, the appearance of a feeling of numbness and compression in the limbs - a symptom of "stocking" and "gloves," convulsions (occur only with rapid administration).

Pyridoxine inhibits lactation, until complete cessation, at a dosage of 200-600 mg / day or more.

Interaction:

Isonicotin hydrazide, penicillamine, cycloserine, oral contraceptives containing estrogens, weaken the effect of pyridoxine.

Pharmaceutically incompatible with vitamins thiamine (B1) and cyanocobalamin (B12).

Pyridoxine is not prescribed together with levodopa, since the effect of the latter is weakened.

Strengthens the action of diuretics.

Combined with cardiac glycosides, glutamic acid, potassium and magnesium asparaginate.

The simultaneous use of pyridoxine with cycloserine, ethionamide, hydralazine, azathioprine, chlorambucil, corticotropin, cyclophosphamide, cyclosporine, mercaptopurine, isoniazid, penicillamine - can cause anemia and neuropathy.

Special instructions:

Vitamin B6 is found in plants and animal organs, especially in unrefined grains of cereals, in vegetables, meat, fish, milk, cod liver and cattle, egg yolk. Relatively a lot of vitamin B6 in yeast.The need for vitamin B6 is satisfied by food: in part it is also synthesized by the intestinal microflora.

With severe liver damage pyridoxine in a dose of more than 50 mg / day can cause a deterioration in its function.

When determining urobilinogen with Eagle's reagent, the results may be distorted.

Effect on the ability to drive transp. cf. and fur:

The adverse effect of the drug on the ability to drive a car and other activities that require concentration and speed of psychomotor reactions have not been reported.

Form release / dosage:

Solution for injection 50 mg / ml.

Packaging:

1 ml or 2 ml into neutral glass ampoules.

For 10 ampoules with instruction for use and a knife for opening ampoules or a scarifier ampullum is placed in a box of cardboard.

5 or 10 ampoules are placed in a contour mesh box made of a polyvinyl chloride film or a polyethylene terephthalate tape and an aluminum foil or paper c. polyethylene coating or without foil, or without paper.

For 1 or 2 contour packs with instructions for use and a knife for opening ampoules or a scarifier ampullum is placed in a pack of cardboard.

When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper is not put in.

Storage conditions:

In the dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N000357 / 01

Date of registration:28.06.2011

The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia

Manufacturer: & nbsp

NOVOSIBHIMFARM, OJSC Russia

Information update date: & nbsp23.09.2015

Illustrated instructions

Instructions

Pyridoxine (Pyridoxine)