Pyridoxine - instructions for use, dose, side effects, contraindications

Vitamin B6, is involved in the metabolism; is necessary for the normal functioning of the central and peripheral nervous system. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate and is part of the enzymes that carry out decarboxylation and reamination of amino acids.

Participates in the metabolism of tryptophan, methionine, cysteine, glutamic and other amino acids. It plays an important role in the exchange of histamine. Promotes the normalization of lipid metabolism. With parkinsonism, the therapeutic effect is manifested in the reduction of tremor.

Vitamin B6 is found in plants and animal organs, especially in unrefined grains of cereals, in vegetables, meat, fish, milk, cod liver and cattle, egg yolk. Relatively a lot of vitamin B6 in yeast.

The need for vitamin B6 is satisfied by food: in part it is also synthesized by the intestinal microflora. Isolated pyridoxine deficiency is very rare, mainly in children on a special artificial diet. It is manifested by diarrhea, convulsions, anemia, peripheral neuropathy can develop.

The daily need for pyridoxine for adults is 2-2.5 mg; for children from 6 months to 1 year - 0.5 mg; 1-1.5 g - 0.9 mg; 1,5-2 years - 1 mg; 3-4 years -1.3 mg; 5-6 years -1,4 mg; 7-10 years - 1.7 mg; 11-13 years - 2 mg; for young men of 14-17 years - 2.2 mg; for girls aged 14-17 - 1.9 mg. For women - 2 mg and in addition at pregnancy 0,3 mg, at feeding by a breast - 0,5 mg.

Pharmacokinetics:

Metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxalphosphate and pyridoxamino phosphate). With plasma proteins binds pyridoxalphosphate by 90%. They are well absorbed and penetrate into all tissues; distribution is predominantly in the liver, less in the muscles and in the central nervous system. Penetrates through the placenta and into the mother's milk. T_1/2- 15-20 days. It is excreted by the kidneys (with intravenous administration with bile - 2%), as well as with hemodialysis.

Indications:

AT₆-Hypovitaminosis.

In complex therapy:

in neurology: Parkinsonism, paralysis of central or peripheral origin, Little's disease, Meniere's disease and syndrome, sea and air disease, radiculitis, neuralgia, neuritis.
in dermatology: dermatitis (including seborrhea), shingles, neurodermatitis, psoriasis, exudative diathesis.
toxicosis of pregnant women, anemia (hypochromic, microcytic, sideroblastic), leukopenia of various etiologies.
acute and chronic hepatitis, alcoholism.
to enhance the action of diuretics.
prevention and treatment of neurotoxicity of isoniazid and other anti-tuberculosis drugs.

Contraindications:

Hypersensitivity to the drug.

Carefully:

With caution should be used pyridoxine hydrochloride in patients with peptic ulcer of the stomach and duodenum (due to the possible increase in the acidity of gastric juice), coronary heart disease.

Dosing and Administration:

Pyridoxine is prescribed intravenously, intramuscularly or subcutaneously (if oral administration is not possible, for example, with vomiting and with intussusception of intestinal absorption).

Adult treatment doses are 50-100 mg (1-2 ml of 5% solution) in 1-2 divided doses per day. The course of treatment is 1-2 months.

Parkinsonism is prescribed 100 mg / day (2 ml of 5% solution per day) intramuscularly. Course of 20-25 injections. After 2-3 months, the course of treatment is repeated.

For the treatment of anemia, 100 mg intramuscularly administered twice a week. It is advisable to simultaneously take folic acid, cyanocobalamin, riboflavin.

In the treatment of tuberculosis GINK (isonicotinic acid hydrazide) and its derivatives (isoniazid, flvivazide etc.) for 1 g of the injected drug should be prescribed 100 mg of pyridoxine (to prevent violations of the functions of the central nervous system).

Side effects:

Allergic reactions, hypersecretion of hydrochloric acid, the appearance of numbness and compression in the limbs - a symptom of "stocking" and "gloves," a decrease in lactation (sometimes it is used as a therapeutic effect), rarely convulsions (occur only with rapid administration).

Interaction:

Isonicotin hydrazide, penicillamine, cycloserine, oral contraceptives containing estrogens, weaken the effect of pyridoxine.

Pharmaceutically incompatible with vitamins B1 and B12.

Pyridoxine is not prescribed together with L-dofa (levodopa), since the action of the latter is weakened.

Strengthens the action of diuretics.

Combined with cardiac glycosides, glutamic acid and asparcam.

Simultaneous use of pyridoxine with cycloserine, ethionamide, hydralazine, azathioprine, chlorambucil, corticotropin, cyclophosphamide, cyclosporine, mercaptopurine, isoniazid, penicillin - can cause anemia and neuropathy.

Special instructions:

With severe liver damage pyridoxine in large doses can cause a deterioration in its function.

When determining urobilinogen using Ehrlich's reagent, it can distort the results.

Form release / dosage:

Ampoules of 1 ml.

Packaging:For 10 ampoules together with instructions for use and a knife for opening ampoules or a scarifier ampoule in a box of cardboard.

Storage conditions:

In the dark place at a temperature of 2 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:П N010973 / 01

Date of registration:31.08.2010

The owner of the registration certificate:LVIVODIALEK DP KAK UKRMEDPROM LVIVODIALEK DP KAK UKRMEDPROM Ukraine

Manufacturer: & nbsp

LVIVODIALEK DP KAK UKRMEDPROM Ukraine

Information update date: & nbsp23.09.2015

Illustrated instructions

Instructions

Pyridoxine (Pyridoxine)