Sinaflan - instructions for use, dose, side effects, contraindications

1 g of liniment contains: active substance - fluocinolone acetonide (sinaflan) - 0.25 mg; auxiliary substances: propylene glycol 49.75 mg, lanolin 100 mg, pentaerythritol dioleate 50 mg, stearic acid 30 mg, methyl parahydroxybenzoate 0.8 mg, propyl parahydroxybenzoate 0.2 mg, water 319 mg, petroleum 450 mg .

Description:

Liniment is yellowish white in color.

Pharmacotherapeutic group:Glucocorticosteroid for topical application

ATX: & nbsp

D.07.A. C.04 Fluocinolone acetonide

Pharmacodynamics:

Fluocinolone acetonide-glucocorticosteroid for topical application. It inhibits the release of inflammatory mediators. When exposed to the skin, the edge accumulation of neutrophils is prevented, which leads to a decrease in inflammatory exudate and production of cytokines; inhibition of migration of macrophages, reduction of infiltration and granulation. Has anti-inflammatory, antiallergic, antiexudative and antipruritic effect. Reduces the appearance or eliminates the inflammatory skin reaction.

Pharmacokinetics:

After absorption from the surface of the skin binds to plasma proteins, it is metabolized in the liver with the formation of inactive metabolites. It is excreted mainly by the kidneys.

Indications:

Eczema, atopic dermatitis, chronic simple zoster (restricted neurodermatitis), drug reaction, a simple allergic dermatitis, seborrheic dermatitis, itching, urticaria, prurigo, diaper rash, erythema multiforme,psoriasis (exudative form); red flat lichen, discoid lupus erythematosus, dyshidrosis of brushes, external otitis, burns I st., insect bites.

Contraindications:

Hypersensitivity, cutaneous manifestations of syphilis, skin tuberculosis, diaper rash, rosacea, extensive psoriatic plaques, anogenital itching; skin infections caused by bacteria, viruses, fungi - pyoderma, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis, trophic ulcers of the shin, associated with varicose veins, erosive and ulcerative lesions of the gastrointestinal tract, wounds on the application areas, skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma, pregnancy, lactation period, children's age (up to 2 years).

Carefully:

At girls in puberty.

Dosing and Administration:

Outwardly. On the previously wiped with a tampon moistened with antiseptic liquid, a small amount of Sinaflana liniment is applied to the skin 2-4 times a day and lightly rubbed. If necessary, you can apply an occlusive bandage, leaving it on the affected surface for up to 3-4 days. It is not allowed to apply under the bandage more than 2 g / day.

Side effects:

Burning, itching, steroid acne, striae, dry skin, folliculitis. With prolonged use - skin atrophy, local hirsutism, hypertrichosis, telangiectasia, purpura, skin pigmentation disorders, alopecia (especially in women), secondary immunodeficiency (exacerbation of chronic infectious diseases, generalization of the infection process, development of opportunistic infections); when applied to large surfaces, systemic manifestations are possible (gastritis, steroid stomach ulcer, adrenal insufficiency, Itenko-Cushing syndrome, steroid diabetes mellitus, slowing of reparative processes).

Overdose:

Symptoms: itching and burning of the skin at the site of application, hyperglycemia, glucosuria, Itenko-Cushing syndrome.

Treatment: symptomatic on the background of a gradual withdrawal of the drug.

Interaction:

Compatible with antimicrobial drugs. Reduces the activity of antihypertensive, diuretic, antiarrhythmic drugs, drugs K +. Diuretic medicines (except potassium-sparing) increase the risk of hypokalemia.

Special instructions:

Apply only short courses on small areas of the skin.The drug should not be applied to the face. Avoid contact with eyes. Duration of appointment in children should not exceed 5 days. It is recommended to wear loose clothes during treatment. In patients with ordinary and rosaceous acne on the background of treatment, the exacerbation of the disease is possible. To prevent local infectious complications, it is recommended to prescribe in combination with antimicrobial agents.

Form release / dosage:

Liniment is 0.025%.

Packaging:

For 15 g in tubes of aluminum or polyethylene laminate. Each tube together with instructions for medical use of the drug is placed in a cardboard box.

Storage conditions:

Store at a temperature not exceeding 20 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use the drug after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000362

Date of registration:02.12.2009

The owner of the registration certificate:Nizhny Novgorod Chemical and Pharmaceutical Plant, OJSCNizhny Novgorod Chemical and Pharmaceutical Plant, OJSC

Manufacturer: & nbsp

NIZHFARM, JSC Russia

Information update date: & nbsp21.10.2015

Illustrated instructions

Instructions

Sinaflan (Sinaflan )