Sinaflan - instructions for use, dose, side effects, contraindications

Glucocorticosteroid for external use; inhibits the release of inflammatory mediators. When exposed to the skin, the edge accumulation of neutrophils is prevented, which leads to a decrease in inflammatory exudate and production of cytokines; inhibition of migration of macrophages, reduction of infiltration and granulation. Has anti-inflammatory and anti-allergic effect.

Pharmacokinetics:

After absorption from the surface of the skin binds to plasma proteins, it is metabolized in the liver with the formation of inactive metabolites. It is excreted mainly by the kidneys.

Indications:

Inflammatory and allergic skin diseases of non-microbial etiology: eczema, atopic dermatitis, simple chronic lichen (limited neurodermatitis), itchy skin, psoriasis and other chronic diseases accompanied by dry skin.

Contraindications:

Hypersensitivity to the components of the drug; skin manifestations of syphilis, skin tuberculosis, diaper rash, rosacea, extensive psoriatic rashes (plaques), anogenital itching; skin infections,caused by bacteria, viruses, fungi - pyoderma, chickenpox, herpes, actinomycosis, blastomycosis, sporotrichosis, trophic ulcers of the shin, associated with varicose veins, erosive and ulcerative lesions of the gastrointestinal tract, wounds in the areas of applications; skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma; pregnancy and lactation period, children's age (up to 2 years).

Carefully:

They are used with caution in girls during puberty.

Dosing and Administration:

Outwardly.

On the previously wiped with a tampon moistened with antiseptic liquid, the skin is applied a small amount of the drug 2-4 times a day and lightly rubbed. If necessary, you can apply an occlusive bandage, leaving it on the affected surface for up to 3-4 days. It is not allowed to apply under the bandage more than 2 g per day. The duration of treatment depends on the nature of the disease and the effectiveness of therapy, usually 5-10 days. If the disease persists, the course of treatment can be extended to 25 days (after consulting a doctor). Children are recommended to use the minimum effective dose, not more than 5 days.

Side effects:

Burning, itching, steroid acne, striae, dry skin, folliculitis. With prolonged use - skin atrophy, local hirsutism, hypertrichosis, telangiectasia, purpura, skin pigmentation disorders, alopecia, especially in women, secondary immunodeficiency (exacerbation of chronic infectious diseases, generalization of the infection process, development of opportunistic infections). When applied to extensive surfaces, systemic manifestations are possible (gastritis, steroid stomach ulcer, adrenal insufficiency, Itenko-Cushing syndrome, steroid diabetes mellitus, slowing of reparative processes).

Overdose:

Symptoms: itching, burning of the skin at the site of application, hyperglycemia, glucosuria, Itenko-Cushing syndrome.

Treatment: symptomatic on the background of a gradual withdrawal of the drug.

Interaction:

Compatible with antimicrobial drugs. Reduces the activity of antihypertensive, diuretic, antiarrhythmic drugs, potassium preparations. Diuretic medicines (except potassium-sparing) increase the risk of hypokalemia.

Special instructions:

Apply only short courses on small areas of the skin.It is recommended to wear loose clothes during treatment. The drug should not be applied to the face. Avoid contact with eyes. With the development of local infectious complications used in combination with antimicrobial drugs.

Effect on the ability to drive transp. cf. and fur:Does not affect

Form release / dosage:

Ointment for external use 0,025 %.

Packaging:

For 10 or 15 grams of aluminum tubes.

By 5, 10, 15, 20, 25, 30, 35 or 50 g in the banks of dark glass type BPS from of glass fiber with stretched covers. On the bank paste label self-adhesive. Each tube or jar along with instructions for use placed in a cardboard box (pack) of cardboard for consumer packagings.

Storage conditions:

In the dark place at temperature not higher than 25 ° С.

Keep out of the reach of children place.

Shelf life:3 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001818

Date of registration:30.08.2012

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp20.10.2015

Illustrated instructions

Instructions

Sinaflan (Sinaflan )