Hypersensitivity to the components of the drug. Anogenital itching, pyoderma, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis, skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma. Infectious skin diseases, skin manifestations of syphilis, skin tuberculosis, diaper rash, rosacea, extensive psoriatic rashes (plaques), trophic ulcers of the lower leg, skin tumors, ulcerous lesions, wounds on the application areas, erosive and ulcerative lesions of the gastrointestinal tract, pregnancy and period of lactation, children's age (up to 2 years).