The drug is administered intravenously. The dosage regimen is set individually, depending on the severity of the course, the localization of the infection and the sensitivity of the pathogen.
Adults and children over 12 years of age: the drug is prescribed in a dose of 1.2 g every 8 hours (3 times a day), in the case of a severe course of infection - every 6 hours (4 times a day).
The maximum daily dose is 6 g.
Children up to 3 months old: premature and in the perinatal period - in a dose of 30 mg / kg (based on the entire drug) 2 times a day, in the postperinatal period - in a dose of 30 mg / kg (calculated on the whole drug) 3 times a day.
Children aged 3 months to 12 years: in a dose of 30 mg / kg (based on the whole drug) 3 times a day; in case of severe infection - 4 times a day.
Duration of treatment is from 5 to 14 days.
For the prevention of postoperative infections in operations lasting less than 1 hour during introductory anesthesia is administered at a dose of 1.2 g. For longer operations, 1.2 g, every 6 hours during the day. With a high risk of infection, administration can be continued for several days.
For patients with renal insufficiency the dose and / or the interval between drug administrations should be adjusted depending on the degree of insufficiency: when creatinine clearance is greater than 30 ml / min, dose reduction is not required; with a creatinine clearance of 10-30 ml / min, treatment starts with the introduction of 1.2 g, then 0.6 g every 12 hours; when the creatinine clearance is less than 10 ml / min - 1.2 g, then 0.6 g / day.
For children, the dose and multiplicity of administration should be reduced in the same way.
Since 85% of the drug is removed by hemodialysis, at the end of each hemodialysis procedure it is necessary to administer the usual dose of the drug.
With peritoneal dialysis, dose adjustments are not required.
Rules for the preparation and administration of solutions for intravenous injection:
Dissolve the contents of the 600 mg (500 mg + 100 mg) vial in 10 ml of water for injection or 1.2 g (1000 mg + 200 mg) in 20 ml of water for injection.
In / in slowly (within 3-4 minutes)
Rules for the preparation and administration of solutions for intravenous infusion:
For infusion administration of the drug, further dilution is necessary: the prepared solutions containing 600 mg (500 mg + 100 mg) or 1.2 g (1000 mg + 200 mg) of the drug should be diluted in 50 ml or 100 ml of the infusion solution, respectively. Duration of infusion 30-40 minutes.
As a solvent for intravenous infusion, the following infusion solutions can be used: isotonic sodium chloride solution, Ringer's solution, potassium chloride solution.