Intravenous (bolus, drip).
The calculation is made by amoxicillin. The dosage regimen is set individually, depending on the severity of the course and localization of the infection, the sensitivity of the pathogen.
With intravenous administration, adults and adolescents over 12 years of age are given 1000 mg 3 times a day, with severe infections 4 times a day. The maximum daily intake of adults and adolescents over 12 years of age (with a body weight of more than 40 kg) is 6000 mg. For children 3 months to 12 years - 25 mg / kg 3 times a day; in severe cases - 4 times a day; for children younger than 3 months with a body weight of less than 4 kg - 25 mg / kg every 12 hours, for children younger than 3 months with a body weight of more than 4 kg -25 mg / kg every 8 hours. In children younger than 3 months the drug should be administered only slowly infusion for 30-40 minutes. Duration of treatment - up to 14 days, acute otitis media - up to 10 days.
For the prevention of postoperative infections in operations lasting less than 1 hour, during the introductory anesthesia is administered at a dose of 1000 mg intravenously. With longer operations - 1000 mg every 6 hours during the day. With a high risk of infection, administration can be continued for several days.
For patients on hemodialysis, dose adjustment is based on the maximum recommended dose of amoxicillin.Initially, a dose of 1000 mg, followed by 500 mg every 24 hours and an additional 500 mg at the end of the hemodialysis session (to compensate for the decrease in plasma concentration of amoxicillin).
For children on hemodialysis, a dose of 25 mg / kg is administered first every 24 hours and additionally (12.5 mg / kg) at the end of the hemodialysis session (to compensate for the reduction in amoxicillin concentration in the serum) and further (25 mg / kg) per day.
In chronic renal failure, dose adjustment and frequency of administration are performed depending on the creatinine clearance: when the creatinine clearance is more than 30 ml / min, dose adjustment is not required; with the clearance of creatinine 10-30 ml / min - IV - 1000 mg, then 500 mg intravenously twice a day; when creatinine clearance is less than 10 ml / min -1000 mg, then 500 mg every 24 hours intravenously. For children with a creatinine clearance of more than 30 ml / min, dose adjustment is not required; with the clearance of creatinine (25 mg / kg) 2 times a day intravenously; when the creatinine clearance is less than 10 ml / min - (25 mg / kg) every 24 hours intravenously.
Patients with impaired liver function are treated with caution, and liver function is monitored regularly. Currently, there is not enough data to change the dosing regimen for such patients.
Preparation of a solution for intravenous injection.
Intravenous injection slowly (within 3-4 minutes).
| Bottles | Solvent (ml)
| The obtained volume (ml) |
| 500/100 mg | 10 | 10,5 |
| 1000/200 mg | 20 | 20,9 |
The solvent is water for injections.
If the dose is 500/100 mg, then the drug is diluted in 10 ml of the solvent. To dilute the dose of 1000/200 mg, use a 20 ml syringe filled with water for injection. 10 ml of the solvent is injected into the vial without removing the needles, the contents of the vial are dissolved, after dissolution of the drug, the solution is taken into the syringe and for shaking the concentration is additionally shaken for 5-10 seconds.
Clamosar should be administered within 20 minutes after the preparation of the solution for intravenous administration.
During the breeding, a temporary pink staining of the solution may appear.
The finished solution has a light yellow color.
Preparation of a solution for intravenous intravenous infusion
Clamosar can be administered as an intravenous infusion for 30-40 minutes. The resulting Klamosar solution at a dose of 500/100 mg and 1000/200 mg is immediately added to 50 ml and 100 ml of the infusion fluid, respectively.
A sufficient concentration of antibiotics is maintained at 25 ° C in the recommended volumes of the infusion solutions listed below, and the infusion should be completed before the expiration of the period indicated in the table below.
| Standard solutions for IV infusion | Stability period with 25 ° С
|
| Water for injections | 4h |
| Sodium chloride chloride 0.9% | 4h |
| Sodium lactate for intravenous infusion 1.85% | 3 hours |
| Ringer's | 3 hours |
| Dr. Hartman (Ringer Lactate) | 3 hours |
| Potassium chloride (0.3%) and sodium chloride (0.9%) for intravenous infusion | 3 hours |
Do not use antibiotic solution residues.