Intravenously.
Doses are given in terms of both active substances (amoxicillin+ clavulanic acid). The dosage regimen is set individually, depending on the severity of the course, the localization of the infection and the sensitivity of the pathogen.
Duration of treatment: 5-14 days. Treatment should not exceed 14 days without repeated medical examination!
Adults and adolescents over 12 years of age or weighing more than 40 kg - by (1000 + 200) mg every 8 hours, with severe infections - every 4-6 hours.
For children weighing less than 40 kg the dose is calculated depending on the body weight:
- children aged 3 months to 12 years - by (25 + 5) mg / kg every 8 hours, with severe infections - every 6 hours;
- children under 3 months of age with a body weight of more than 4 kg - (25 + 5) mg / kg every 8 hours;
- children under 3 months of age with a body weight of less than 4 kg - (25 + 5) mg / kg every 12 hours.
In children younger than 3 months, the drug should be injected only slowly infusion for 30-40 minutes.
For the prevention of postoperative infections at operations, less than 1 hour, during the introductory anesthesia is administered intravenously in a dose (1000 + 200) mg. With longer operations - by (1000 + 200) mg every 6 hours during the day. With a high risk of infection, administration can be continued for several days.
Preparation of solutions for intravenous injection:
Dosage (500 + 100) mg: dissolve the contents of the vial in 10 ml of water for injection. Dosage (1000 + 200) mg: dissolve the contents of the vial in 20 ml of water for injection. Enter slowly, for 3-4 minutes.
Preparation of a solution for intravenous infusion:
Dosage (500 + 100) mg: dissolve the contents of the vial in 10 ml of water for injection and add the resulting solution to 50 ml of infusion fluid.
Dosage (1000 + 200) mg: dissolve the contents of the vial in 20 ml of water for injection and add the resulting solution to 100 ml of infusion fluid.
Infusion is carried out for 30-40 minutes.
Stability and compatibility:
Intravenous injections should be made immediately after dissolution. Do not freeze the solution. Do not use the solution left after the intravenous injection. Intravenous infusions can be carried out in various solutions:
| Infusion liquids: | Stability at 25 ° С |
| Water for injections | 4 hours |
| A solution of sodium chloride 0.9% | 4 hours |
| Ringer's solution | 3 hours |
| Solution of potassium chloride and sodium chloride complex for intravenous administration | 3 hours |
Preparations are less stable in infusion solutions containing dextrose, dextran or sodium bicarbonate.
Therapy, initiated with intravenous administration, in the case of a positive reaction of the patient, can be continued with the corresponding oral form of the drug.
Dosage for renal failure:
For patients with impaired renal function, the dose and / or interval between drug administrations should be adjusted according to the degree of renal failure:
| Age | Creatinine clearance | Dosage |
| Adults | Easy insufficiency (> 30 ml / min) | Correction of dose is not required |
| Insufficiency of medium degree (10-30 ml / min) | The initial dose is -1.2 g (1000 mg + 200 mg), then 600 mg (500 mg + 100 mg) every 12 hours |
| Severe insufficiency (<10 ml / min) | The initial dose is -1.2 g (1000 mg + 200 mg), then 600 mg (500 mg + 100 mg) every 24 hours |
| Children | Appropriate dose adjustment is required |
Dosage with functional liver failure:
Patients with signs of liver damage should regularly check its function. If necessary, the dose should be reduced.