Inside. The dosage regimen is set individually depending on the patient's body weight, severity of the course and localization of the infectious process, as well as the sensitivity of the pathogen.
The minimum course of antibiotic therapy is from 5 days. Treatment should not be continued for more than 14 days without reviewing the clinical situation. The duration of treatment of acute uncomplicated otitis media is 5-7 days, in children under 2 years - 7-10 days.
A single dose is established depending on the age and body weight (calculation for amoxicillin):
- children up to 3 months - 30 mg / kg / day in 2 divided doses;
- children from 3 months and older:
- low doses (for treatment of skin and soft tissue infections, as well as chronic tonsillitis) - 20 mg / kg / day in 3 divided doses;
- high doses (for treatment of otitis media, sinusitis, lower respiratory tract infections, urinary tract infections) - 40 mg / kg / day in 3 divided doses. Children weighing 40 kg or more should be given doses as adults.
The suspension can be used in adults with difficulty swallowing.
Recommended dosage regimen for adults: 20 ml of suspension in a dosage of 125 mg + 31.25 mg / 5 ml or 10 ml of suspension at a dosage of 250 mg + 62.5 mg / 5 ml 2-3 times a day.
The maximum daily dose of amoxicillin for adults and children over 12 years is 6 g, for children under 12 years, 45 mg / kg of body weight.
The maximum daily dose of clavulanic acid for adults and children over 12 years is 600 mg, for children under 12 years of age it is 10 mg / kg of body weight.
Patients with impaired renal function:
Correction of doses is based on the maximum recommended dose of amoxicillin and the value of creatinine clearance.
- Children
Creatinine clearance more than 30 ml / min dose adjustment is not required;
Creatinine clearance 10-30 ml / min - 15 mg / 3.75 mg / kg 2 times a day, the maximum dose of 500 mg + 125 mg (20 ml of suspension at a dosage of 125 mg + 31.25 mg / 5 ml or 10 ml of a suspension in a dosage of 250 mg + 62.5 mg / 5 ml) twice a day;
Creatinine clearance less than 10 ml / min - 15 mg / 3.75 mg / kg once a day, maximum daily dose of 500 mg + 125 mg (20 ml of suspension at a dosage of 125 mg + 31.25 mg / 5 ml or 10 ml of a suspension in a dosage of 250 mg + 62.5 mg / 5 ml);
- Adults
Creatinine clearance more than 30 ml / min dose adjustment is not required;
Creatinine clearance 10-30 ml / min - 500 mg + 125 mg (20 ml suspension at a dosage of 125 mg + 31.25 mg / 5 ml or 10 ml suspension at a dosage of 250 mg + 62.5 mg / 5 ml) 2 times in day;
creatinine clearance less than 10 mL / min - 500 mg + 125 mg (20 ml of a suspension at a dose of 125 mg + 31.25 mg / 5 ml or 10 ml of the suspension at a dosage of 250 mg + 62.5 mg / 5 mL) 1 time per day ;
Patients on hemodialysis:
Correction of doses is based on the maximum recommended dose of amoxicillin
- Children - 15 mg / 3.75 mg / kg once a day.
Before a hemodialysis session, one additional dose of 15 mg / 3.75 mg / kg should be taken. To restore the concentration of the active components of the drug in the blood, a second additional dose of 15 mg / 3.75 mg / kg should be taken after a hemodialysis session.
- Adults - 500 mg + 125 mg (20 ml of a suspension at a dose of 125 mg + 31.25 mg / 5 ml or 10 ml of the suspension at a dosage of 250 mg + 62.5 mg / 5 ml) once every 24 hours.
Additional 1 dose during the dialysis session and one dose at the end of the dialysis session (to compensate for the reduction in serum concentrations of amoxicillin and clavulanic acid)
Method of preparation of the suspension:
Suspension is prepared immediately before use.
Powder in vial pre-shaken, then adding a small amount of boiled and cooled to room temperature, water was stirred to give a uniform suspension, and then water was added to the mark on the vial.To accurately dispense the suspension, you should use a dosage double-sided spoon, which you need to rinse well with water after each application. After reconstitution, the suspension should be stored for no more than 7 days in the refrigerator, but not frozen.