The dosage regimen is set individually depending on the age, body weight, function of the patient's kidneys, and also on the severity of the infection.
Treatment should not last more than 14 days without reviewing the clinical situation. The drug Augmentin is not intended for intramuscular administration (due to instability at a concentration that could be administered intramuscularly).Doses are given in terms of the active ingredients: amoxicillin and clavulanic acid.
Adults and children over 12 years of age or with a body weight of 40 kg or more
Infections of mild to moderate severity: a dose of 1000 mg + 200 mg every 8 hours.
Severe infections: a dose of 1000 mg + 200 mg every 4-6 hours.
Prophylaxis in surgery
Interventions lasting less than 1 h: a dose of 1000 mg + 200 mg during the initial anesthesia.
Interventions lasting more than 1 hour: 1 dose of 1000 mg + 200 mg during anesthesia and then up to 4 doses of 1000 mg + 200 mg for 24 hours.
Special patient groups
Children
For children weighing less than 40 kg, the dose is calculated depending on the body weight. In children younger than 3 months, the drug Augmentin ® should be administered only slowly infusion for 30-40 minutes.
Less than 3 months with a body weight of less than 4 kg
25 mg amoxicillin and 5 mg clavulanic acid per 1 kg body weight every 12 hours. Less than 3 months with a body weight of more than 4 kg
25 mg of amoxicillin and 5 mg of clavulanic acid per 1 kg of body weight every 8 hours.
From 3 months to 12 years with a body weight of less than 40 kg
25 mg amoxicillin and 5 mg clavulanic acid per 1 kg body weight every 6-8 hours, depending on the severity of the infection.
Elderly patients
Dosage adjustment, dosing as in adult patients is not required. Patients with impaired renal function
Correction of the dosing regimen is based on the maximum recommended dose of amoxicillin.
Adults
| Creatinine clearance> 30 ml / min | Correction of the dosing regimen is not required. |
| Creatinine clearance 10-30 ml / min | The initial dose of 1000 mg + 200 mg and further 500 mg + 100 mg 2 times a day. |
| Creatinine clearance <10 ml / min | The initial dose of 1000 mg + 200 mg and further 500 mg + 100 mg every 24 hours. |
Children
| Creatinine clearance> 30 ml / min | Correction of the dosing regimen is not required. |
| Creatinine clearance 10-30 ml / min | 25 mg + 5 mg per 1 kg 2 times a day. |
| Creatinine clearance <10 ml / min | 25 mg + 5 mg per 1 kg every 24 hours. |
Patients, on hemodialysis
Correction of the dosing regimen is based on the maximum recommended dose of amoxicillin.
Adults
Initially, 1 dose of 1000 mg + 200 mg, followed by 500 mg + 100 mg every 24 hours and an additional 500 mg + 100 mg at the end of the hemodialysis session (to compensate for the decrease in amoxicillin and clavulanic acid levels in the blood plasma).
Children
25 mg of amoxicillin and 5 mg of clavulanic acid per 1 kg of body weight every 24 hours and an additional 12.5 mg of amoxicillin and 2.5 mg of clavulanic acid per kg of body weight at the end of the hemodialysis session (to compensate for the decrease in amoxicillin and clavulanic acid levels in blood plasma ) and further 25 mg of amoxicillin and 5 mg of clavulanic acid per 1 kg of body weight per day.
Patients with impaired hepatic function
Treat with caution; regularly monitor liver function.
There is insufficient data to change the recommendation for doses in such patients.
Mode of application
Bolus injection
The drug Augmentin can be administered as a slow intravenous injection of 3-4 minutes duration directly into the vein or through a catheter.
The contents of 1 bottle are diluted in 20 ml of water for injection, the total volume of the solution is 20.9 ml. During the preparation, the solution may acquire a pink color that disappears afterwards. The finished solution can have a color from colorless to light-straw.
The resulting solution should be introduced within 20 minutes after dilution.
Infusion introduction
The drug Augmentin® is administered intravenously drip for 30-40 minutes.
The solution prepared as described above for bolus administration without delay is added to 100 ml of one of the infusion solutions listed in the table below.
| Infusion solutions | Stability period at 25 ° C (hours) |
| Water for injections | 4 |
| A solution of sodium chloride 0.9% | 4 |
| Sodium lactate solution for intravenous administration | 4 |
| Ringer's solution | 3 |
| Ringer's lactate solution according to Hartman | 3 |
The solution prepared at room temperature can be stored under the same conditions, and the infusion must be completed before the expiration of the period indicated in the table above. The solution can be stored at 5 ° C for 8 hours. To this end, the solution prepared as described above for bolus administration is added to a pre-chilled vial with 100 ml of infusion water or 100 ml of 0.9% sodium chloride solution.
Solutions that were stored at a temperature of 5 ° C, must be entered immediately after they reach room temperature.
The stability of the solution of the combination of amoxicillin with clavulanic acid depends on the concentration. If more concentrated solutions are needed, the stability time of the solution will change accordingly.
Any remaining amounts of solution must be destroyed.
Vials of the drug Augmentin® are not intended for repeated use.