The drug is administered intravenously (IV).
The dosage regimen depends on the age, body weight and function of the patient's kidneys, and also on the severity of the infection.
The minimum course of antibiotic therapy is 5 days. The maximum duration of therapy can be 14 days, after which its effectiveness and tolerability should be assessed.
Doses are given for the content of amoxicillin / clavulanic acid.
Adults and children older than 12 years weighing more than 40 kg
Infections of mild and moderate severity: 1000 mg / 200 mg every 8 hours.
Severe infections: 1000 mg / 200 mg every 4-6 hours.
Prophylaxis in surgery
Interventions lasting less than 1 hour; 1000 mg / 200 mg during the initial anesthesia Interventions lasting more than 1 hour: 1000 mg / 200 mg during the initial anesthesia and then to 4 doses of 1000 mg / 200 mg for 24 hours.
Patients with impaired renal function
Dose adjustment is based on the maximum recommended dose of amoxicillin.
| Creatinine clearance> 30 ml / min | Correction of dose is not required |
| Creatinine clearance 10-30 ml / min | Initially, 1000 mg / 200 mg and further 500 mg / 100 mg twice daily |
| Creatinine clearance <10 ml / min | Initially 1000 mg / 200 mg and further 500 mg / 100 mg every 24 hours |
Patients on hemodialysis
Dose adjustment is based on the maximum recommended dose of amoxicillin.
Initially, a dose of 1000 mg / 200 mg, followed by 500 mg / 100 500 mg / 100 mg at the end of the hemodialysis session (for amoxicillin and clavulanic acid in plasma) is administered.
Patients with impaired hepatic function
Treat with caution; regularly monitor liver function.
Children
For children weighing less than 40 kg, the dose is calculated depending on the body weight.
Less than 3 months with a body weight of less than 4 kg (25 mg / 5 mg) / kg every 12 hours.
Less than 3 months with a body weight of more than 4 kg (25 mg / 5 mg) / kg every 8 hours.
In children younger than 3 months, the drug should be injected only slowly infusion for 30-40 minutes.
From 3 months to 12 years
(25 mg / 5 mg) / kg every 6-8 hours, depending on the severity of the infection.
Children with impaired renal function
Dose adjustment is based on the maximum recommended dose of amoxicillin.
| Creatinine clearance> 30 ml / min | Correction of dose is not required |
| Creatinine clearance 10-30 ml / min | (25 mg / 5 mg) / kg 2 times a day. |
| Creatinine clearance <10 ml / min | (25 mg / 5 mg) / kg every 24 hours. |
Children on hemodialysis
Correction of the dose is based on the maximum recommended content of amoxicillin. (25 mg / 5 mg) / kg every 24 hours and additionally (12.5 mg / 2.5 mg / kg at the end of the hemodialysis session (to compensate for the reduction in amoxicillin and clavulanic acid in the serum) and further (25 mg / 5 mg) / kg per day.
Children with impaired liver function
Treat with caution; regularly monitor liver function.
Mode of application
Bolus injection
The powder is diluted with water for injection.
| Proportion / solvent ratio |
| Bottle | Solvent (ml) |
| 1000 mg / 200 mg | 20 |
The drug can be administered as a slow intravenous injection lasting 3-4 minutes directly into the vein orthrough the catheter.
The resulting solution must be introduced within 20 minutes after breeding.
Infusion introduction:
The drug is administered intravenously drip for 30-40 minutes, previously dissolving the powder in the volume of water for injection indicated in the table above, the resulting solution is added to 100 ml of the solvent: 0.9% sodium chloride solution, sodium lactate solution for intravenous administration, Ringer's solution, solution Ringer's lactate for Hartman.