Increases the concentration in the blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol.
Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous application with deferoxamine.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption.
With simultaneous application with ASA, urinary excretion of ascorbic acid increases and ASA excretion decreases. ASA reduces the absorption of ascorbic acid by about 30%.
Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.
Increases the total clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Preparations of quinoline series (fluoroquinolones, etc.), calcium chloride, salicylates, glucocorticosteroids with long-term use deplete the stores of ascorbic acid.
With simultaneous use reduces the chronotropic effect of isoprenaline.
With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol.
In high doses increases the renal excretion of mexiletine.
Barbiturates and primidon increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotic agents (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.