Ascorbic acid - instructions for use, dose, side effects, contraindications

Vitamin product provides metabolic action, is not formed in the human body, but comes only with food.Participates in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood coagulability, tissue regeneration, in the synthesis of steroid hormones; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. It has pronounced antioxidant properties. Regulates hydrogen transport in many biochemical reactions, improves the use of glucose in the cycle of tricarboxylic acids, participates in the formation of tetrahydrofolic acid and regeneration of tissues, the synthesis of steroid hormones, collagen, procollagen. It supports the colloidal state of the intercellular substance and the normal permeability of capillaries (oppresses hyaluronidase). Activates proteolytic enzymes, participates in the exchange of aromatic amino acids, pigments and cholesterol, promotes the accumulation of glycogen in the liver. Due to the activation of respiratory enzymes in the liver, it enhances its detoxification and protein-forming functions, increases the synthesis of prothrombin. It improves bile secretion, restores the exocrine function of the pancreas and the endocrine function of the pancreas.

Indications:

Prevention and treatment of hypo- and vitamin deficiency of vitamin C;

As an auxiliary: hemorrhagic diathesis, nasal, uterine, pulmonary and other bleedings, including those caused by radiation sickness; overdose of anticoagulants, diseases of the gastrointestinal tract, accompanied by a violation of absorption of vitamin C; injury. Conditions accompanied by increased demand for vitamin C: increased physical and mental stress, the period of pregnancy and breastfeeding, the period of recovery after long-term illness.

Contraindications:

Hypersensitivity to the components of the drug, thrombophlebitis, a tendency to thrombosis, diabetes mellitus.

Carefully:

Hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, progressive malignant diseases, pregnancy, oxalosis, kidney stone disease.

Pregnancy and lactation:

The minimum daily requirement for ascorbic acid in II-III trimesters of pregnancy - about 60 mg.

The minimum daily requirement for breastfeeding is 80 mg. A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent the deficiency of vitamin C in an infant.

During pregnancy and breastfeeding, the recommended dosage of ascorbic acid should not be exceeded.

Dosing and Administration:

Inside, after eating. Powder is used to make drinks -1 g (the contents of a single sachet bag) of ascorbic acid powder - per 1 liter of water or 2.5 g of ascorbic acid powder (contents of one sachet bag) per 2.5 liters of water. The solution is taken freshly prepared, according to the dosages proposed below.

For dosing, the use of a medical measuring cup is recommended.

For prophylaxis: adults 50 mg-100 mg (50 ml-100 ml) per day, children from 5 years of 50 mg (50 ml) per day.

For treatment: adults 50 mg-100 mg (50 ml-100 ml) 3-5 times a day, children from 5 years to 50 mg (50 ml) -100 mg (100 ml) 2-3 times a day.

During pregnancy and breastfeeding 300 mg (300 ml) per day for 10-15 days, then - 100 mg (100 ml) per day.

For adults: the maximum single dose of -200 mg, daily -1 g, gdlyadetey-50-100 mg / day.

Note: the medical measuring cup is not included in the kit.

Side effects:

From the central nervous system (CNS): headache, fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.

From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.

From the endocrine system: oppression of the insular pancreas function (hyperglycemia, glucosuria).

From the urinary system: when used in high doses - hyperoxalaturia and the formation of urinary stones from calcium oxalate.

From the side of the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy

Allergic reactions: skin rash, rarely - anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Other: hypervitaminosis, a sensation of fever, with prolonged use of large doses - the retention of sodium and liquid, the disruption of the exchange of zinc, copper.

If any side effects occur, stop taking the medication and consult a doctor.

Overdose:

When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating and / or staining the urine red, hemolysis (in patients with deficiency of glucose-6-phosphate dehydrogenase) are possible.

If symptoms of an overdose occur, consult a doctor.

Interaction:

Increases the concentration in the blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol. Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous application with deferoxamine.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption. With simultaneous application with ASA, urinary excretion of ascorbic acid increases and ASA excretion decreases. ASA reduces the absorption of ascorbic acid by about 30%. Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows down the excretion kidney acid, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration in the blood of oral contraceptives.Increases the total clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body. Preparations of quinoline series (fluoroquinolones, etc.), calcium chloride, salicylates, glucocorticosteroids with long-term use deplete the stores of ascorbic acid. With simultaneous use reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol. In high doses increases the renal excretion of mexiletine. Barbiturates and primidon increase the excretion of ascorbic acid in the urine. W Reduces the therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

Reduces the effectiveness of heparin and indirect anticoagulants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the synthesis glucocorticosteroid hormones, it is necessary to monitor kidney function and arterial pressure. With prolonged use of large doses, it is possible oppression of the insular pancreas function, so in The process of treatment should be regularly monitored.In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses. Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. Ascorbic acid, as a reductant, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).

Form release / dosage:

Powder for solution for oral administration.

Packaging:

For 1 g, 2.5 grams in heat-sealing bags of the material of a combined film croft or from paper with a polymeric coating.

10 or 100 packets together with the instruction for use are placed in a cardboard box.

2000 packages with instructions for use in the proper amount in a cardboard box.

Storage conditions:

In dry, protected from light, out of reach of children, at a temperature not exceeding 25 ° C.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-005546/07

Date of registration:29.12.2007

Expiration Date:Unlimited

The owner of the registration certificate:ROSFARM, CJSC ROSFARM, CJSC Russia

Manufacturer: & nbsp

ROSFARM, CJSC Russia

Information update date: & nbsp26.09.2017

Illustrated instructions

Instructions

Ascorbic acid (Ascorbic asid)