Ascorbic acid - instructions for use, dose, side effects, contraindications

Ascorbic acid actively participates in many oxidation-reduction reactions, it has a nonspecific general stimulating effect on the body. Increases the adaptive abilities of the body and its resistance to infections; promotes regeneration processes.

Indications:

Prevention and treatment of hypo- and vitamin deficiency vitamin C.

As an auxiliary: hemorrhagic diathesis, nasal, uterine, pulmonary hemorrhages; an overdose of anticoagulants; diseases of the gastrointestinal tract, accompanied by a violation of absorption of vitamin C; sluggishly healing wounds.

Increased physical and mental stress, the period of pregnancy and breastfeeding, the period of recovery after severe long-term illnesses.

Contraindications:

Hypersensitivity to the components of the drug, thrombophlebitis, a tendency to thrombosis, diabetes mellitus.

Carefully:

Hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia,progressive malignant diseases, pregnancy.

Pregnancy and lactation:

The minimum daily requirement for ascorbic acid in II-III trimesters of pregnancy - about 60 mg.

The minimum daily requirement for breastfeeding is 80 mg. A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent the deficiency of vitamin C in an infant (it is recommended not to exceed the maximum daily requirement for ascorbic acid by the nursing mother).

Dosing and Administration:

The drug is taken orally after a meal.

For prophylaxis: adults 0.05-0.1 g (1-2 tablets) a day, children from 5 years of 0.05 g (1 tablet) per day.

For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times a day, children from 5 years to 0.05-0.1 g (1-2 tablets) 2-3 times a day day.

During pregnancy and breastfeeding, 0.3 g (6 tablets) a day for 10-15 days, then 0.1 g (2 tablets) per day.

Side effects:

From the central nervous system (CNS): headache, a feeling of fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.

From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.

From the endocrine system: oppression of the insular pancreas function (hyperglycemia, glucosuria).

From the urinary system: when used in high doses - hyperoxalaturia and the formation of urinary stones from calcium oxalate.

From the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, the development of microangiopathies, myocardial dystrophy.

Allergic reactions: skin rash, rarely anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprotrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Other: hypervitaminosis, a feeling of heat, with prolonged use of large doses - sodium retention (Na⁺) and fluids, the disruption of zinc metabolism (Zn²⁺), copper (Cu²⁺).

Overdose:

When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating or staining the urine red, hemolysis (in patients with a deficiency of glucose-6-phosphate dehydrogenase) are possible.

If any side effects occur, stop taking the medication and consult a doctor.

Interaction:

Increases the concentration in the blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol.

Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous application with deferoxamine.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption.

With simultaneous application with ASA, urinary excretion of ascorbic acid increases and ASA excretion decreases. ASA reduces the absorption of ascorbic acid by about 30%.

Increases the risk of developing Crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.

Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid to the body.

Preparations of quinoline series (fluoroquinolones, etc.), calcium chloride, salicylates, glucocorticosteroids with long-term use deplete the stores of ascorbic acid.

With simultaneous use reduces the chronotropic effect of isoprenaline.With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol.

In high doses increases the renal excretion of mexiletine.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the kidney function and arterial pressure.

With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).

Form release / dosage:

Dragee.

Packaging:200 pieces in a polymer can.

Storage conditions:

Stored in a dry place, protected from light and the reach of children at 15 to 25 ° C.

Shelf life:

1 year 6 months. Do not use after the time specified on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-000049

Date of registration:27.04.2007

Expiration Date:Unlimited

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Information update date: & nbsp26.09.2017

Illustrated instructions

Instructions

Ascorbic acid (Ascorbic asid)