Askovit - instructions for use, dose, side effects, contraindications

Active substance:
Ascorbic acid - 500.00 mg
Auxiliary substances for lemon tablets: sodium bicarbonate 605.00 mg, sorbitol 721.00 mg, citric acid 765.00 mg, macrogol 30.00 mg, saccharin 6.00 mg, aspartame 20.00 mg, quinoline yellow color (E-104) 1.50 mg , dye E-101 (riboflavin) 1.50 mg, flavor "Limon" 50.00 mg
Auxiliary substances for orange tablets: sodium bicarbonate 1.0 mg, sorbitol 714.70 mg, citric acid 630.00 mg, macrogol 30.00 mg, saccharin 6.0 mg, aspartame 20.00 mg, coloring sunset yellow sunset (E-110) 1 D0 mg, flavoring "Orange" 58.00 mg.

Description:

Lemon: Ploskotsilindricheskie tablets yellow-orange with a pinkish hue of color with lighter and darker patches, with a facet and a risk, with a weak specific odor.

Orange: Ploskotsilindricheskie tablets pale orange with pinkish a shade of color with lighter and darker inclusions, with a facet and a risk, with a weak specific odor.

Pharmacotherapeutic group:Vitamin

ATX: & nbsp

A.11.G.A.01 Ascorbic acid

Pharmacodynamics:

Ascorbic acid is not formed in the human body, but comes only with food. With an unbalanced and malnutrition, a person experiences a deficiency in vitamin C.

Ascorbic acid (vitamin C) plays an important role in regulating oxidation-reduction processes, carbohydrate metabolism, blood clotting, tissue regeneration; participates in the synthesis of corticosteroids, collagen and procollagen; normalizes the permeability of capillaries.Participates in the metabolism of iron, enhances the absorption of non-heme iron. It has antiplatelet and pronounced antioxidant activity. Participates in the exchange of aromatic amino acids, pigments and cholesterol, promotes the accumulation of glycogen in the liver.

Due to the activation of respiratory enzymes in the liver, it intensifies its detoxification and protein-forming functions, increases the synthesis of prothrombin.

It inhibits the release and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other mediators of inflammation and allergic reactions.

Regulates immunological reactions (activates the synthesis of antibodies, C3-component of complement, interferon). Promotes phagocytosis, increases the body's resistance to infections.

Pharmacokinetics:

Absorbed in the gastrointestinal tract (mainly in the jejunum). Connection with plasma proteins - 25%. Diseases of the gastrointestinal tract (GIT) reduce the absorption of ascorbic acid in the intestine. The maximum concentration of ascorbic acid in the blood is reached 4 hours after ingestion. Easily penetrates into leukocytes, platelets,and then - in all tissues; the greatest concentration is achieved in glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of the seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates the placenta. Metabolized mainly in the liver. It is excreted by the kidneys, through the intestines, with sweat, breast milk in unchanged form and in the form of metabolites.

Smoking and the use of ethanol accelerate the destruction of ascorbic acid, dramatically reducing stocks in the body.

Indications:

Prevention and treatment of hypo- and vitamin deficiency vitamin C.

Contraindications:

Hypersensitivity, with long-term use in large doses (more than 500 mg) - hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glnozo-6-phosphate dehydrogenase deficiency, sugarase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, phenylketonuria, childhood.

Carefully:

With diabetes, sideroblastic anemia, nephrolithiasis.

Pregnancy and lactation:

Ascorbic acid penetrates the placental barrier. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a newborn can develop ascorbic disease as a withdrawal reaction. Therefore, in pregnancy, do not take ascorbic acid in elevated doses, except when the expected benefit exceeds the potential risk.

Ascorbic acid is excreted in breast milk, therefore, it is recommended not to exceed the maximum daily requirement for ascorbic acid by the nursing mother, unless the expected benefit exceeds the potential risk.

Dosing and Administration:

Inside.

After eating, pre-dissolving the tablet in half a glass of water.

For prophylactic purposes - 500 mg / day, with a therapeutic purpose - 1000 mg / day.

Side effects:

From the side of the central nervous system: with prolonged use of large doses (more than 1000 mg) - headache, increased excitability of the central nervous system, insomnia.

From the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg / day); with prolonged use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate); damage to the glomerular apparatus of the kidneys.

From the digestive system: irritation of the mucous membrane of the gastrointestinal tract; with prolonged use of large doses - nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract.

From the side of the cardiovascular system: with prolonged use of large doses, the drop in capillary permeability (possibly worsening tissue trophism, increased blood pressure, hypercoagulability, development of microangiopathies).

Allergic reactions: skin rash, skin hyperemia.

From the urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones from calcium oxalate.

Other: oppression of the insular pancreas function (hyperglycemia, glucosuria).

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Overdose:

Symptoms: diarrhea, nausea, irritation of the mucous membrane of the gastrointestinal tract, flatulence, abdominal pain of a spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.

Interaction:

Increases the concentration in the blood of benzylpenicillin and tetracyclines. Improves the absorption of iron in the intestine. Reduces the effectiveness of heparin and indirect anticoagulants. Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, reduces the concentration of oral contraceptives in the blood.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the adrenals and arterial pressure.

With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process Ascorbic acid as the reductant can distort the results of various laboratory tests (blood glucose, bilirubin, the activity of "liver" transaminases and lactate dehydrogenase).

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the psychomotor functions associated with driving a car or controlling cars and mechanisms.

Form release / dosage:

Tablets effervescent (orange, lemon) 0,5 g.

Packaging:

For 10, 12, 14 tablets in a plastic pencil case. For 1 pencil case in a cardboard bundle or bundle-envelope with a device for hanging along with instructions for use.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children!

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:П N010434

Date of registration:05.04.2012

Expiration Date:Unlimited

The owner of the registration certificate:Natur Product Europe BVNatur Product Europe BV Netherlands

Manufacturer: & nbsp

NATUR PRODUKT EUROPE, B.V. Netherlands

Information update date: & nbsp20.03.2018

Illustrated instructions

Instructions

Ascovit® (Ascovit)