Ascorbic acid-UBF - instructions for use, dose, side effects, contraindications

Excipients: sugar (sugar) 85.9 mg, starch treacle 13.3 mg, sunflower oil 0.2 mg, food flavors 0.03 mg, bees wax 0.2 mg, talc 0.3 mg, yellow water-soluble dye (KF 6001) (E 104 quinoline yellow) - 0.03 mg.

Description:The dragees are greenish-yellow or yellow in color.

Pharmacotherapeutic group:Vitamin

ATX: & nbsp

A.11.G.A.01 Ascorbic acid

Pharmacodynamics:

Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food.

Ascorbic acid has a metabolic effect, participates in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood clotting, tissue regeneration; increases the adaptive abilities of the body and its resistance to infections, promotes regeneration processes.

Indications:

Treatment and prevention of hypovitaminosis C.

States of increased need for ascorbic acid: the period of artificial feeding and intensive growth, unbalanced nutrition, increased mental and physical loads, recovery period after severe illnesses, alcoholism, burn disease, febrile state against the background of ARI, ARVI; long-term chronic infections, nicotine dependence, stress, postoperative period, pregnancy (multiple birth, against nicotine or drug dependence).

Contraindications:

Hypersensitivity to the components of the drug, thrombophlebitis, propensity to thrombosis; with prolonged use in large doses (more than 500 mg) - diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency, children under 6 years.

Carefully:

Diabetes mellitus, renal stone disease, polycythemia, leukemia, sideroblastic anemia, sickle cell anemia.

Pregnancy and lactation:

The minimum daily requirement for ascorbic acid in II-III trimesters of pregnancy - about 60 mg.

The minimum daily requirement for breastfeeding is 80 mg.

A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent the deficiency of vitamin C in an infant (it is recommended not to exceed the maximum daily requirement for ascorbic acid by the nursing mother).

It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a "cancellation" syndrome may develop in a newborn.

Dosing and Administration:

Ascorbic acid dragees are taken orally after meals.

For prophylaxis: adults 0.05-0.1 g per day (1-2 tablets), children from 6 years old - 0.05 grams (1 pills) per day.

For treatment: adults 0.05-0.1 grams (1-2 tablets) 3-5 times a day, children from 6 years of 0.05-0.1 grams (1-2 tablets) 2-3 times a day day.

At pregnancy and thoracal feeding - on 0,3 g (6 dragees) per day within 10-15 days, further - on 0,1 г (2 dragees) in day.

Side effects:

In rare cases, allergic reactions are possible: skin rash, skin hyperemia.

From the central nervous system: with prolonged use of large doses (more than 1000 mg) - headache, increased excitability of the central nervous system, insomnia.

From the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg / day), with prolonged use of large doses - damage to the glomerular apparatus of the kidneys.

From the digestive system: with prolonged use of large doses - nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract.

From the side of the cardiovascular system: with prolonged use of large doses, a decrease in the permeability of capillaries (possibly worsening tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Laboratory indicators: glucosuria, oppression of the insular pancreas function (hyperglycemia, glucosuria)

Other: sensation of heat.

Overdose:

Symptoms: diarrhea, nausea, irritation of the mucous membrane of the gastrointestinal tract, flatulence, abdominal pain of a spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.

If any side effects occur, stop taking the medication and consult a doctor.

Interaction:

Increases the concentration in the blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including that of oral contraceptives).

Reduces the effectiveness of heparin and indirect anticoagulants.

Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous use with deferoxamine.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption.

With simultaneous application with ASA, urinary excretion of ascorbic acid increases and the excretion of ASA decreases.ASA reduces the absorption of ascorbic acid by about 30%.

Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.

Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

The drugs of quinoline series, calcium chloride, salicylates, glucocorticosteroids with long-term use deplete the stores of ascorbic acid.

With simultaneous use reduces the chronotropic effect of isoprenaline.

With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol.

In high doses increases the excretion of mexiletine by the kidneys.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the adrenals and arterial pressure.

With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of "liver" transaminases and lactate dehydrogenase).

Form release / dosage:Dragee 50 mg each.

Packaging:

By 50, 100, 150, 200 pieces in cans of polymer. Each bank along with the instruction for use is placed in a pack of cardboard for consumer packaging.

Polymer cans with an equal number of instructions for use are placed in a box of cardboard.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:P N002145 / 01

Date of registration:05.12.2008

Expiration Date:Unlimited

The owner of the registration certificate:URALBIOFARM, OJSC URALBIOFARM, OJSC Russia

Manufacturer: & nbsp

URALBIOFARM, OJSC Russia

Information update date: & nbsp19.09.2017

Illustrated instructions

Instructions

Ascorbic acid-UBF (Ascorbic acid-UBF)