Asvitol - instructions for use, dose, side effects, contraindications

Excipients: sucrose (sugar) 177.9 mg, aspartame 3.0 mg, magnesium stearate 3.0 mg, stearic acid 1.0 mg, talc 6.7 mg, low molecular weight povidone (low molecular weight polyvinylpyrrolidone) 5 , 7 mg, ethyl cellulose - 1,3 mg, dye sunset yellow - 1.0 mg, flavoring orange - 0.4 mg.

Description:Tablets from pinkish-orange to orange, flat-cylindrical, with a facet and risk, with impregnations, with a faint fruity smell.

Pharmacotherapeutic group:Vitamin

ATX: & nbsp

A.11.G.A.01 Ascorbic acid

Pharmacodynamics:

Participates in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood coagulability, tissue regeneration, in the synthesis of steroid hormones; increases the body's resistance, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Satisfies the increased needs of the body in vitamin C, with diseases accompanied by fever.

Indications:

Prevention and treatment of hypo- and vitamin deficiency of vitamin C;

As an auxiliary: hemorrhagic diathesis, nasal, uterine, pulmonary and other bleedings, including those caused by radiation sickness; an overdose of anticoagulants, sluggishly healing wounds and fractures of bones, dystrophy, increased physical and mental stress, during recovery after severe, long-term illnesses.

Contraindications:

Hypersensitivity to the components of the drug, thrombophlebitis, a tendency to thrombosis, diabetes mellitus, kidney stone disease, children's age.

Carefully:

Hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle-cell anemia, progressive malignant diseases, pregnancy.

Pregnancy and lactation:

The minimum daily requirement for ascorbic acid in II-III trimesters of pregnancy - about 60 mg.

The minimum daily requirement for breastfeeding is 80 mg. A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent vitamin C deficiency in an infant (it is recommended not to exceed the maximum monthly requirement for ascorbic acid in the nursing mother).

Dosing and Administration:

The drug is taken orally after a meal. The tablet should be chewed and washed down with a small amount of water.

For prevention: adults 200 mg (1 tablet) per day.

For medical purposes: adults 1-2 tablets 1 2 times a day (maximum therapeutic dose - 1 g per day).

Side effects:

From the central nervous system (CNS): headache, fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.

From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.

From the endocrine system: oppression of the function of the insular apparatus pancreas (hyperglycemia, glucosuria).

From the urinary system: when used in high doses - hyperoxaluria and the formation of urinary stones from calcium oxalate.

From the side of the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy

Allergic reactions: skin rash, rarely - anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Other: hypervitaminosis, a feeling of heat, with prolonged use of large doses - sodium retention (Na⁺) and fluids, the disruption of zinc metabolism (Zn²⁺), copper (Cu²⁺). Intensive consumption of chewable tablets or resorption of oral forms can cause damage to tooth enamel.

Overdose:

When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating and / or staining the urine red, hemolysis (in patients with deficiency of glucose-6-phosphate dehydrogenase) are possible.

If any side effects occur, stop taking the medication and consult a doctor.

Interaction:

Increases the concentration in the blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol. Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous application with deferoxamine.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption. With simultaneous application with ASA, urinary excretion of ascorbic acid increases and ASA excretion decreases. ASA reduces the absorption of ascorbic acid by about 30%. Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.Increases the total clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body. Preparations of quinoline series (fluoroquinolones, etc.), calcium chloride, salicylates, glucocorticosteroids with long-term use deplete the stores of ascorbic acid. With simultaneous use reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol. In high doses increases the renal excretion of mexiletine.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

Reduces the effectiveness of heparin, indirect anticoagulants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the adrenals and arterial pressure. With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses. Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. Ascorbic acid, as a reductant, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).

Form release / dosage:

Tablets chewing 200 mg.

Packaging:

For 10 or 20 tablets in a contour mesh package.

For 20, 30 or 50 tablets per can of polymer.

1, 2 or 3 contour squares or 1 jar with instructions for use in the pack.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N000031 / 01

Date of registration:09.07.2010 / 25.05.2015

Expiration Date:Unlimited

The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia

Manufacturer: & nbsp

PHARMSTANDART-FORESTRY, OJSC Russia

Information update date: & nbsp14.09.2017

Illustrated instructions

Instructions

Asvitol® (Asvitol®)