Askovit - instructions for use, dose, side effects, contraindications

With taste of carcade and green tea: sucrose 2758.0 mg, aspartame 15.0 mg, acesulfame potassium 15.0 mg, flavoring "green tea" 42.0 mg, green tea extract 30.0 mg, hibiscus (carcade) extract 30.0 mg, elderberry extract 110 , 0 mg.

With the taste of an orange: sucrose 2839.6 mg, citric acid 80.0 mg, aspartame 15.2 mg, acesulfame potassium 15.2 mg, flavoring "orange" 48.0 mg, dye sunset yellow 2.0 mg.

Description:

Powder with taste of carcade and green tea: powder of varying degrees of granulation, consisting of particles from white, pink, beige to brown and dark brown, with a specific odor. Partial clumping of the powder is possible.

Powder with orange taste: powder of varying degrees of granulation, consisting of particles from white, cream to light pink and light orange, with a specific odor. Partial clumping of the powder is possible.

Pharmacotherapeutic group:Vitamin

ATX: & nbsp

A.11.G.A.01 Ascorbic acid

Pharmacodynamics:

Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food; pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), almost no effect, except for the rapid elimination of symptoms of hypo- and avitaminosis (scurvy); physiological functions: is a cofactor of some hydroxylation and amidation reactions - transfers electrons to enzymes,providing them with a replacement equivalent; participates in hydroxylation reactions (post-translational modification of collagen), oxidation of the side chains of lysine in proteins to form gidroksitrimetillizina (during synthesis kartinita), folic acid, folinic to oxidation, metabolism of drugs in the liver microsomes and hydroxylation of dopamine to noradrenaline form; increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin; participates in steroidogenesis in the adrenal glands; restores Fe ³⁺ before Fe ²⁺ in the intestines, contributing to its absorption; the primary role in the tissue - part in the synthesis of collagen, proteoglycans, and other organic components of the intercellular substance of the teeth, bones and capillary endothelium; in low doses (150-250 mg / day inwards) improves the complexing function of deferoxamine in chronic drug intoxication Fe, which leads to increased excretion of the latter.

Pharmacokinetics:

Absorbed in the gastrointestinal tract (mainly in the jejunum). Connection with plasma proteins - 25%.Diseases of the gastrointestinal tract (GIT) reduce the absorption of ascorbic acid in the intestine. The maximum concentration of ascorbic acid in the blood is reached 4 hours after ingestion. Easily penetrates into leukocytes, platelets, and then into all tissues; the greatest concentration is achieved in glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of the seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates the placenta. Metabolized mainly in the liver. It is excreted by the kidneys, through the intestines, with sweat, breast milk in unchanged form and in the form of metabolites.

Smoking and the use of ethanol accelerate the destruction of ascorbic acid, dramatically reducing stocks in the body.

Indications:

Treatment of hypo- and vitamin deficiency of vitamin C.

Contraindications:

Hypersensitivity, with prolonged use in high doses (more than 500 mg) - hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency, sugarase / isomaltase deficiency,intolerance to fructose, glucose-galactose malabsorption, phenylketonuria, pregnancy, the period of breastfeeding, children's age.

Carefully:

With diabetes, sideroblastic anemia, nephrolithiasis.

Pregnancy and lactation:

Ascorbic acid penetrates the placental barrier. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a newborn can develop ascorbic disease as a withdrawal reaction. Therefore, in pregnancy, do not take ascorbic acid in elevated doses, except when the expected benefit exceeds the potential risk.

Ascorbic acid is excreted in breast milk, therefore, it is recommended not to exceed the maximum daily requirement for ascorbic acid by the nursing mother, unless the expected benefit exceeds the potential risk.

Dosing and Administration:

The contents of the bag dissolve, stirring, in a glass of warm water. Take inside after eating.

The maximum daily dose is 1000 mg (1 sachet).

The course of application is not more than three days in a row, the possibility of prolonging the course should be consulted with a doctor.

Side effects:

From the central nervous system (CNS): with prolonged use of large doses (more than 1000 mg) - headache, increased excitability of the central nervous system, insomnia.

From the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg / day); with prolonged use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate); damage to the glomerular apparatus of the kidneys.

From the digestive system: irritation of the mucous membrane of the gastrointestinal tract; with prolonged use of large doses - nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract.

From the side of the cardiovascular system: with prolonged use of large doses, a decrease in the permeability of capillaries (possibly worsening tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Allergic reactions: skin rash, skin hyperemia.

From the urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones fromcalcium oxalate.

Other: oppression of the insular pancreas function (hyperglycemia, glucosuria).

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Overdose:

Symptoms: diarrhea, nausea, irritation of the mucous membrane of the gastrointestinal tract, flatulence, abdominal pain of a spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.

Interaction:

Increases the concentration in the blood of benzylpenicillin and tetracyclines. Improves the absorption of iron in the intestine. Reduces the effectiveness of heparin and indirect anticoagulants. Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, reduces the concentration of oral contraceptives in the blood.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the adrenals and arterial pressure.

With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. Ascorbic acid as the reductant can distort the results of various laboratory tests (blood glucose, bilirubin, the activity of "liver" transaminases and lactate dehydrogenase).

In one bag with taste karkade and green tea contains 2.758 g of sugar, which corresponds to 0.23 XE.

In one bag with the taste of orange contains 2.8396 g. Of sugar, which corresponds to 0.24 XE.

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the psychomotor functions associated with driving a car or controlling cars and mechanisms.

Form release / dosage:

Powder for solution for ingestion 1000 mg.

Packaging:

By 4.0 grams of powder in a bag of A1 / PET / polyethylene.

For 1, 10, 15, 20, 30 bags in a cardboard box with instructions for use.

Storage conditions:

At a temperature of 10 to 30 ° C.

Keep out of the reach of children!

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001360

Date of registration:15.12.2011 / 30.04.2014

Expiration Date:15.12.2016

The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia

Manufacturer: & nbsp

NATUR PRODUKT PHARMA, Sp. z o.o. Poland

Representation: & nbspVALEANT LLC VALEANT LLC Russia

Information update date: & nbsp19.09.2017

Illustrated instructions

Instructions

Ascovit® (Ascovit®)