Acid ascorbic (vitamin C) - instructions for use, dose, side effects, contraindications

Ascorbic acid actively participates in oxidation-reduction reactions, has a nonspecific general stimulating and antioxidant effect on the body. Increases the adaptive abilities of the body and its resistance to infections; promotes regeneration processes.

Indications:

Prevention and treatment of hypo- and vitamin deficiency vitamin C.

As an auxiliary: hemorrhagic diathesis, nasal, uterine, pulmonary and other hemorrhages, radiation sickness; an overdose of anticoagulants, infectious diseases and intoxications, liver disease, nephropathy of pregnant women, Addison's disease, sluggishly healing wounds and bone fractures, dystrophy and other pathological processes. The drug is prescribed for increased physical and mental stress, during pregnancy and breastfeeding, intensive growth, with stress, during recovery after long and severe illness.

Contraindications:

Hypersensitivity to the components of the drug, thrombophlebitis, a tendency to thrombosis, diabetes mellitus.

Carefully:

Hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle-cell anemia, progressive malignant diseases, pregnancy.

Pregnancy and lactation:

The minimum daily requirement for ascorbic acid in II-III trimesters of pregnancy - about 60 mg.

The minimum daily requirement for breastfeeding is 80 mg. A mother's diet containing an active amount of ascorbic acid is sufficient to prevent vitamin C deficiency in an infant (it is recommended not to exceed the maximum monthly requirement for ascorbic acid in a nursing mother).

Dosing and Administration:

The drug is taken orally after a meal. Before consumption, chew.

For prophylaxis: for adults, 0,05-0,1 g (2-4 tablets) per day; children over 5 years of 0.05 g (2 tablets) per day.

For treatment: adults 0.05-0.1 g (2-4 tablets) 3-5 times a day; children over 5 years of 0.05-0.1 g (2-4 tablets) 2-3 times a day.

During pregnancy and breastfeeding, 0.3 g per day for 10-15 days, then 0.1 g (4 tablets) per day.

The duration of the course of treatment with the drug is determined by the doctor.

Side effects:

From the central nervous system (CNS): headache, fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbance.

From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.

From the endocrine system: oppression of the insular pancreas function (hyperglycemia, glucosuria).

From the urinary system: when used in high doses - hyperoxalaturia and the formation of urinary stones from calcium oxalate.

From the side of the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy.

Allergic reactions: skin rash, rarely - anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia: erythropenia, neutrophilic leukocytosis, hypokalemia.

Other: hypervitaminosis, a feeling of heat, with prolonged use of large doses - sodium retention (Na⁺) and fluid, a disruption of zinc metabolism (Zn²⁺), copper (Cu²⁺).

Overdose:

When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating and / or staining the urine red, hemolysis (in patients with deficiency of glucose-6-phosphate dehydrogenase) are possible.

If any side effects occur, stop taking the medication and consult a doctor.

Interaction:

Increases the concentration in the blood of antibiotics of the penicillin group and tetracyclines; in a dose of 1 g / day. increases the bioavailability of ethinyl estradiol.

Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous application with deferoxamine.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption.

When used simultaneously with ASA, ascorbic acid is excreted in the urine and ASA excretion decreases. ASA reduces the absorption of ascorbic acid by about 30%.

Increases the risk of developing crystalluria when combined with salicylates and sulfonamidesshort-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Preparations of quinoline series (fluoroquinolones, etc.), calcium chloride, salicylates, glucocorticosteroids with prolonged use deplete the supply of ascorbic acid.

With simultaneous use reduces the chronotropic effect of isoprenaline.

With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol.

In high doses increases the renal excretion of mexiletine.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic agents (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, it is necessary to monitor the indices of arterial pressure.

With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity.

Form release / dosage:Tablets are chewable.

Packaging:

10 tablets are wrapped in a label-label of a Polyphan film or from a base paper for waxing. 10 pack labels are wrapped in paper (intermediate packing) from a parchment or wrapping paper.

For 40 intermediate packages, together with instructions for use in the quantity corresponding to the number of label packages, are put in a box.

Storage conditions:

Store in a dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

1 year.

The drug should be used before the date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N011921 / 01

Date of registration:03.04.2008 / 11.04.2012

Expiration Date:Unlimited

The owner of the registration certificate:KIEVSKY VITAMIN FACTORY, PAOKIEVSKY VITAMIN FACTORY, PAO Ukraine

Manufacturer: & nbsp

KIEVSKY VITAMIN FACTORY, PAO Ukraine

Representation: & nbspArt Bureau Ltd.Art Bureau Ltd.Russia

Information update date: & nbsp11.01.2018

Illustrated instructions

Instructions

Acidum ascorbicum (vitamin C) (Ascorbic asid (vitamin C))